Two new 3,4-seco-labdane diterpenoids from Callicarpa nudiflora and their inhibitory activities against nitric oxide production

被引：22

作者：

Dong, Lin ^{[1
,2
]}

Zhang, Lei ^{[3
]}

Zhang, Xiaopo ^{[1
]}

Liu, Mingsheng ^{[4
]}

Wang, Jinhui ^{[3
]}

Wang, Yi ^{[5
]}

机构：

[1] Hainan Med Univ, Coll Pharm, Haikou 571199, Peoples R China

[2] Hainan Med Univ, Hainan Prov Key Lab R&D Trop Med Plants, Haikou 571199, Peoples R China

[3] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

[4] Acad South Med & Li Med Hainan Prov, Haikou 571199, Peoples R China

[5] Ocean Univ China, Sch Med & Pharm, Chinese Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2014年 / 10卷

基金：

中国国家自然科学基金;

关键词：

Callicarpa nudiflora; 3,4-seco-Labdane diterpenoid; Nitric oxide production; ENT-3,4-SECO-LABDANE DITERPENOIDS; LEAVES;

D O I：

10.1016/j.phytol.2014.08.014

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new 3,4-seco-labdane diterpenoids, callicarpaolide (1) and callicarpic acid A (2) were isolated from the leaves of Callicarpa nudiflora. Their structures were elucidated by 1D and 2D NMR spectroscopy and high resolution mass spectrometry. The absolute configuration of 1 was assigned by the application of the CD technique. Compounds 1 and 2 showed potent inhibitory activity against the production of nitric oxide (NO) in LPS-activated macrophage cell line, RAW 264.7 cells. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：127 / 131

页数：5

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