Two new 3,4-seco-labdane diterpenoids from Callicarpa nudiflora and their inhibitory activities against nitric oxide production

被引：20
作者：
Dong, Lin [1 ,2 ]
Zhang, Lei [3 ]
Zhang, Xiaopo [1 ]
Liu, Mingsheng [4 ]
Wang, Jinhui [3 ]
Wang, Yi [5 ]
机构：
[1] Hainan Med Univ, Coll Pharm, Haikou 571199, Peoples R China
[2] Hainan Med Univ, Hainan Prov Key Lab R&D Trop Med Plants, Haikou 571199, Peoples R China
[3] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China
[4] Acad South Med & Li Med Hainan Prov, Haikou 571199, Peoples R China
[5] Ocean Univ China, Sch Med & Pharm, Chinese Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2014年 / 10卷
基金：
中国国家自然科学基金;
关键词：
Callicarpa nudiflora; 3,4-seco-Labdane diterpenoid; Nitric oxide production; ENT-3,4-SECO-LABDANE DITERPENOIDS; LEAVES;
D O I：
10.1016/j.phytol.2014.08.014
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new 3,4-seco-labdane diterpenoids, callicarpaolide (1) and callicarpic acid A (2) were isolated from the leaves of Callicarpa nudiflora. Their structures were elucidated by 1D and 2D NMR spectroscopy and high resolution mass spectrometry. The absolute configuration of 1 was assigned by the application of the CD technique. Compounds 1 and 2 showed potent inhibitory activity against the production of nitric oxide (NO) in LPS-activated macrophage cell line, RAW 264.7 cells. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：127 / 131
页数：5
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