2-(anilinomethyl)imidazolines as α1 adrenergic receptor agonists:: α1a subtype selective 2′-heteroaryl compounds

被引：17

作者：

Speake, JD ^{[1
]}

Navas, F ^{[1
]}

Bishop, MJ ^{[1
]}

Garrison, DT ^{[1
]}

Bigham, EC ^{[1
]}

Hodson, SJ ^{[1
]}

Saussy, DL ^{[1
]}

Liacos, JA ^{[1
]}

Irving, PE ^{[1
]}

Sherman, BW ^{[1
]}

机构：

[1] GlaxoSmithKline, Res Triangle Pk, NC 27709 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(03)00050-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The structure-activity relationship of 2'-pyrrole, pyrazole and triazole substituted 2-(anilinomethyl)imidazolines as alpha(1) adrenergic agonists was investigated. The size and orientation of substituents, as well as the position of the heteroatoms, were found to have a profound effect on the potency and selectivity of the molecules. Potent alpha(1A) subtype selective agonists have been identified. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1183 / 1186

页数：4

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