Stem cells as vectors for antitumour therapy

被引：83
|
作者：
Loebinger, Michael R. [1 ]
Janes, Sam M. [1 ]
机构：
[1] UCL, Ctr Resp Res, Rayne Inst, London WC1E 6JJ, England
来源：
THORAX | 2010年 / 65卷 / 04期
基金：
英国医学研究理事会;
关键词：
MARROW STROMAL CELLS; CANCER GENE-THERAPY; ACUTE MYOCARDIAL-INFARCTION; LUNG METASTASIS MODEL; BONE-MARROW; IN-VITRO; CHEMOKINE RECEPTORS; BREAST-CANCER; TARGETED-DELIVERY; PROGENITOR CELLS;
D O I：
10.1136/thx.2009.128025
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Recent research suggests that mesenchymal stem cells (MSCs) are able to migrate specifically to tumours and their metastases throughout the body. This has led to considerable excitement about the possibility of modifying these cells to express anticancer molecules and using them as specific targeted anticancer agents. However, there are concerns that systemically delivered MSCs may have non-desirable effects, and there are also many unanswered questions including the mechanism of tumour homing. This review investigates the different MSC-delivered anticancer agents, addresses the questions and concerns, and tries to place this potential therapy in future cancer management.
引用
收藏
页码：362 / 369
页数：8
相关论文
共 50 条
  • [41] Mesenchymal stem cells in cancer therapy; the art of harnessing a foe to a friend
    Karimi-Shahri, Mehdi
    Javid, Hossein
    Mashhad, Alireza Sharbaf
    Yazdani, Shaghayegh
    Hashemy, Seyed Isaac
    IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2021, 24 (10) : 1307 - 1323
  • [42] Challenges in identifying the best source of stem cells for cardiac regeneration therapy
    Dixit, Parul
    Katare, Rajesh
    STEM CELL RESEARCH & THERAPY, 2015, 6
  • [43] The clinical application of mesenchymal stem cells and cardiac stem cells as a therapy for cardiovascular disease
    Kim, Jiyeon
    Shapiro, Linda
    Flynn, Aidan
    PHARMACOLOGY & THERAPEUTICS, 2015, 151 : 8 - 15
  • [44] A Review of Stem Cell Translation and Potential Confounds by Cancer Stem Cells
    Bibber, Bernadette
    Sinha, Garima
    Lobba, Aline R. M.
    Greco, Steven J.
    Rameshwar, Pranela
    STEM CELLS INTERNATIONAL, 2013, 2013
  • [45] Clinical applications of mesenchymal stem cells
    Wang, Shihua
    Qu, Xuebin
    Zhao, Robert Chunhua
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2012, 5
  • [46] The immunomodulatory properties of mesenchymal stem cells
    Marigo, Ilaria
    Dazzi, Francesco
    SEMINARS IN IMMUNOPATHOLOGY, 2011, 33 (06) : 593 - 602
  • [47] Migratory Properties of Mesenchymal Stem Cells
    Dittmar, Thomas
    Entschladen, Frank
    MESENCHYMAL STEM CELLS: BASICS AND CLINICAL APPLICATION I, 2013, 129 : 117 - 136
  • [48] Mesenchymal Stem Cells: Angels or Demons?
    Wong, Rebecca S. Y.
    JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2011,
  • [49] Application of mesenchymal stem cells exosomes as nanovesicles delivery system in the treatment of breast cancer
    Liu, Xiaofan
    Kim, June Hyun
    Li, Xuemei
    Liu, Rui
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2024, 666
  • [50] Pluripotent stem cells, a potential source of β-cells for diabetes therapy
    Hansson, Mattias
    Madsen, Ole D.
    CURRENT OPINION IN INVESTIGATIONAL DRUGS, 2010, 11 (04) : 417 - 425
12345