Stem cells as vectors for antitumour therapy

被引：83
|
作者：
Loebinger, Michael R. [1 ]
Janes, Sam M. [1 ]
机构：
[1] UCL, Ctr Resp Res, Rayne Inst, London WC1E 6JJ, England
来源：
THORAX | 2010年 / 65卷 / 04期
基金：
英国医学研究理事会;
关键词：
MARROW STROMAL CELLS; CANCER GENE-THERAPY; ACUTE MYOCARDIAL-INFARCTION; LUNG METASTASIS MODEL; BONE-MARROW; IN-VITRO; CHEMOKINE RECEPTORS; BREAST-CANCER; TARGETED-DELIVERY; PROGENITOR CELLS;
D O I：
10.1136/thx.2009.128025
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Recent research suggests that mesenchymal stem cells (MSCs) are able to migrate specifically to tumours and their metastases throughout the body. This has led to considerable excitement about the possibility of modifying these cells to express anticancer molecules and using them as specific targeted anticancer agents. However, there are concerns that systemically delivered MSCs may have non-desirable effects, and there are also many unanswered questions including the mechanism of tumour homing. This review investigates the different MSC-delivered anticancer agents, addresses the questions and concerns, and tries to place this potential therapy in future cancer management.
引用
收藏
页码：362 / 369
页数：8
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