Rhodium(III)-Catalyzed Three-Component Reaction of Imines, Alkynes, and Aldehydes through C-H Activation

被引：57

作者：

Huang, Ji-Rong ^{[1
]}

Song, Qiang ^{[1
]}

Zhu, Yu-Qin ^{[1
]}

Qin, Liu ^{[1
]}

Qian, Zhi-Yong ^{[2
]}

Dong, Lin ^{[1
,2
]}

机构：

[1] Sichuan Univ, West China Sch Pharm, Minist Educ, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Peoples R China

[2] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 51期

关键词：

C-H activation; cyclization; multicomponent reactions; rhodium; CATALYZED 3+2 ANNULATION; N-SULFONYL KETIMINES; MULTICOMPONENT REACTIONS; BOND FUNCTIONALIZATION; INTERNAL ALKYNES; INTERMOLECULAR HYDROACYLATION; SECONDARY BENZAMIDES; EFFICIENT SYNTHESIS; AROMATIC KETIMINES; FACILE SYNTHESIS;

D O I：

10.1002/chem.201404576

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient rhodium(III)-catalyzed tandem three-component reaction of imines, alkynes and aldehydes through C-H activation has been developed. High stereo-and regioselectivity, as well as good yields were obtained in most cases. The simple and atom-economical approach offers a broad scope of substrates, providing polycyclic skeletons with potential biological properties.

引用

页码：16882 / 16886

页数：5

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