Rhodium(III)-Catalyzed Three-Component Reaction of Imines, Alkynes, and Aldehydes through C-H Activation

被引：57

作者：

Huang, Ji-Rong ^{[1
]}

Song, Qiang ^{[1
]}

Zhu, Yu-Qin ^{[1
]}

Qin, Liu ^{[1
]}

Qian, Zhi-Yong ^{[2
]}

Dong, Lin ^{[1
,2
]}

机构：

[1] Sichuan Univ, West China Sch Pharm, Minist Educ, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Peoples R China

[2] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 51期

关键词：

C-H activation; cyclization; multicomponent reactions; rhodium; CATALYZED 3+2 ANNULATION; N-SULFONYL KETIMINES; MULTICOMPONENT REACTIONS; BOND FUNCTIONALIZATION; INTERNAL ALKYNES; INTERMOLECULAR HYDROACYLATION; SECONDARY BENZAMIDES; EFFICIENT SYNTHESIS; AROMATIC KETIMINES; FACILE SYNTHESIS;

D O I：

10.1002/chem.201404576

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient rhodium(III)-catalyzed tandem three-component reaction of imines, alkynes and aldehydes through C-H activation has been developed. High stereo-and regioselectivity, as well as good yields were obtained in most cases. The simple and atom-economical approach offers a broad scope of substrates, providing polycyclic skeletons with potential biological properties.

引用

页码：16882 / 16886

页数：5

共 109 条

[1] [Anonymous], 2012, ANGEW CHE
[2] [Anonymous], 2011, ANGEW CHEM
[3] [Anonymous], 2012, ANGEW CHEM
[4] [Anonymous], 2013, ANGEW CHEM
[5] [Anonymous], 2011, ANGEW CHEM
[6] [Anonymous], CHEM COMMUN
[7] Multiple-component condensation strategies for combinatorial library synthesis
Armstrong, RW
Combs, AP
Tempest, PA
Brown, SD
Keating, TA
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1996, 29 (03) : 123 - 131
[8] Using Rh(III)-Catalyzed C-H Activation as a Tool for the Selective Functionalization of Ketone-Containing Molecules
Boultadakis-Arapinis, Melissa
Hopkinson, Matthew N.
Glorius, Frank
[J]. ORGANIC LETTERS, 2014, 16 (06) : 1630 - 1633
[9] Brodney M. A., 2011, Patent Appl. WO, Patent No. [2011/125006 A2, 2011125006]
[10] Synthesis of dihydropyridines and pyridines from Imines and alkynes via C-H activation
Colby, Denise A.
Bergman, Robert G.
Ellman, Jonathan A.
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (11) : 3645 - 3651

← 1 2 3 4 5 6 7 8 9 10 →