Layered double hydroxide as gene reservoir

被引：0

作者：

Choy, JH ^{[1
]}

Park, JS ^{[1
]}

Kwak, SY ^{[1
]}

Jeong, YJ ^{[1
]}

Han, YS ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Nat Sci, Ctr Mol Catalysis, Dept Chem, Seoul 151742, South Korea

来源：

MOLECULAR CRYSTALS AND LIQUID CRYSTALS | 2000年 / 341卷

关键词：

bio-/organic-inorganic hybrid; intercalation; gene and drug reservoir; encapsulation; layered double hydroxide;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel bio-/organic-inorganic hybrid compounds of deoxyribonucleic acid (DNA) and methotrexate (MTX)-layered double hydroxide are prepared by ion-exchange type intercalation reaction, The layered inorganic support, Mg2Al(NO3)-LDH, is at first obtained by coprecipitation in an aqueous solution. and then the interlayer NO3- anions are replaced by guest molecules such as methotrexate (an anticancer drug) and deoxyribonucleic acid (about 500 similar to 1000 base pairs), lending to form new bio-/organic-nanohybrids. Upon intercalating guest molecules into hydroxide layers, the basal spacing of LDH increases from 8.5 Angstrom (NO3-) to 20.8 Angstrom (MTX) and 23.9 Angstrom (DNA), respectively. According to the X-ray diffraction and infrared spectroscopic analyses, it is found that the target molecules are safely preserved by hydroxide layers maintaining their chemical and structural properties.

引用

页码：1229 / 1233

页数：5

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