Pharmacokinetics of Quercetin and Other Flavonols Studied by Liquid Chromatography and LC-MS (a Review)

被引：1

作者：

Guglya, E. B. ^{[1
]}

机构：

[1] Pirogov Russian Natl Res Med Univ, Inst Basic & Appl Biomed Res, Moscow 117997, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2014年 / 48卷 / 08期

关键词：

quercetin; flavonols; flavonoids; flavonoid pharmacokinetics; bioanalytical methods; liquid chromatography-mass spectrometry (LC-MS/MS); TANDEM MASS-SPECTROMETRY; TIME-OF-FLIGHT; RAT PLASMA; IN-VITRO; MS/MS METHOD; METABOLITES; EXTRACT; QUANTIFICATION; IDENTIFICATION; HPLC;

D O I：

10.1007/s11094-014-1137-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Modern analytical methods used to study the pharmacokinetics of quercetin and other flavonols, i.e., biologically active compounds that exhibit various therapeutic properties, were reviewed. The preparation of biological fluids and tissues for analysis, chromatography conditions, and mass spectrometric detection for various flavonols as the aglycons and glycosides and their metabolites were discussed. Quantitative analyses of flavonol concentrations in biological samples and their mass spectrometric identification in in vitro and in vivo studies during tests with pure compounds and multi-constituent plant extracts were presented as typical examples.

引用

页码：489 / 498

页数：10

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