Small-Molecule Inhibition of Glucose Transporters GLUT-1-4

被引:72
作者
Reckzeh, Elena S. [1 ,2 ]
Waldmann, Herbert [1 ,2 ]
机构
[1] Max Planck Inst Mol Physiol, Dept Chem Biol, Otto Hahn Str 11, D-44227 Dortmund, Germany
[2] TU Dortmund Univ, Dept Chem & Chem Biol, Otto Hahn Str 4a, D-44227 Dortmund, Germany
基金
欧洲研究理事会;
关键词
antitumor agents; cancer; drug discovery; GLUT inhibitors; metabolism; BREAST-CANCER CELLS; CYTOCHALASIN-B; MYCOBACTERIUM-TUBERCULOSIS; T-CELLS; GENE-EXPRESSION; LUNG-CARCINOMA; IN-VITRO; GLUT1; GLYCOLYSIS; METABOLISM;
D O I
10.1002/cbic.201900544
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Glucose addiction is observed in cancer and other diseases that are associated with hyperproliferation. The development of compounds that restrict glucose supply and decrease glycolysis has great potential for the development of new therapeutic approaches. Addressing facilitative glucose transporters (GLUTs), which are often upregulated in glucose-dependent cells, is therefore of particular interest. This article reviews a selection of potent, isoform-selective GLUT inhibitors and their biological characterization. Potential therapeutic applications of GLUT inhibitors in oncology and other diseases that are linked to glucose addiction are discussed.
引用
收藏
页码:45 / 52
页数:8
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