Employing Unnatural Amino Acids in the Preparation of Biooconjugates

被引：14

作者：

Maza, Johnathan C. ^{[1
]}

Jacobs, Taylor H. ^{[1
]}

Uthappa, Diya M. ^{[1
]}

Young, Douglas D. ^{[1
]}

机构：

[1] Coll William & Mary, Dept Chem, POB 8795, Williamsburg, VA 23187 USA

来源：

SYNLETT | 2016年 / 27卷 / 06期

关键词：

bioconjugations; unnatural amino acids; cycloadditions; biorthogonal; Glaser-Hay coupling; SITE-SPECIFIC INCORPORATION; COPPER-FREE; BIOORTHOGONAL REACTIONS; PROTEIN; CHEMISTRY; ALKYNE; CYCLOADDITION; ANTIBODIES; BIOCONJUGATION; PEGYLATION;

D O I：

10.1055/s-0035-1560551

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The exploitation of unnatural amino acid (UAA) technologies represents an excellent mechanism for the generation of site-specific bioconjugates. Consequently, significant effort has been invested in the advancement of the technology via the integration of novel bioconjugation reactions and the expansion of the set of UAAs that can be employed. Herein, we report the recent developments in the field and highlight advantages and disadvantages of various UAA bioconjugation reactions.

引用

页码：805 / 813

页数：9

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