Oxidant-responsive ferrocene-based cyclodextrin complex coacervate core micelles

被引：11

作者：

Facciotti, Camilla ^{[1
]}

Saggiomo, Vittorio ^{[1
]}

van Hurne, Simon ^{[1
]}

Bunschoten, Anton ^{[1
]}

Kaup, Rebecca ^{[1
]}

Velders, Aldrik H. ^{[1
]}

机构：

[1] Wageningen Univ & Res, Lab BioNanoTechnol, Bornse Weilanden 9, NL-6708 WG Wageningen, Netherlands

来源：

SUPRAMOLECULAR CHEMISTRY | 2020年 / 32卷 / 01期

关键词：

Host-guest; cyclodextrin; stimuli-responsive; ferrocene; complex coacervate core micelles; DRUG-DELIVERY; BLOCK-COPOLYMER; POLYMERS; INCLUSION;

D O I：

10.1080/10610278.2019.1685094

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Coacervate-core micelles are considered promising materials for several applications, from catalysis to drug delivery. However, oxidant-responsive coacervate-core micelles, able to undergo structural changes upon specific oxidation stimuli, are not well reported. Here, we present a novel ferrocene-dipicolinic acid derivative as redox-responsive subcomponent to be incorporated in cyclodextrin-based coacervate core micelles, C4Ms, with tuneable core structure and responsiveness towards H2O2 treatment. The Fc-C4Ms are formed combining three orthogonal supramolecular interactions, namely (i) metal-to-ligand coordination between europium(III) ions and dipicolinic acid molecules, (ii) host-guest interaction between beta cyclodextrins and ferrocenes and (iii) electrostatic coacervation interaction. The micelle stability against oxidation can be controlled by varying three main parameters: (a) the core-unit structure, from monomeric metal complexes to supramolecular oligomers, (b) the H2O2 equivalents and c) the ratio between redox-responsive and non-redox-responsive bislinker. The H2O2-responsive ferrocene-based systems might have an interesting application, e.g. reactive oxygen species-mediated drug delivery. [GRAPHICS] .

引用

页码：30 / 38

页数：9

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