Transcutaneous Electrical Stimulation for Neurogenic Bladder Dysfunction Following Spinal Cord Injury: Meta-Analysis of Randomized Controlled Trials

被引：16

作者：

Parittotokkaporn, Sam ^{[1
,2
]}

Varghese, Chris ^{[3
]}

O'Grady, Gregory ^{[3
,4
]}

Lawrence, Anna ^{[5
]}

Svirskis, Darren ^{[6
]}

O'Carroll, Simon J. ^{[1
,2
]}

机构：

[1] Univ Auckland, Sch Med Sci, Dept Anat & Med Imaging, Fac Med & Hlth Sci, Auckland, New Zealand

[2] Univ Auckland, Ctr Brain Res, Auckland, New Zealand

[3] Univ Auckland, Dept Surg, Fac Med & Hlth Sci, Auckland, New Zealand

[4] Univ Auckland, Auckland Bioengn Inst, Auckland, New Zealand

[5] Counties Manukau Hlth, Auckland Spinal Rehabil Unit ASRU, Auckland, New Zealand

[6] Univ Auckland, Sch Pharm, Fac Med & Hlth Sci, Auckland, New Zealand

来源：

NEUROMODULATION | 2021年 / 24卷 / 07期

关键词：

Meta‐ analysis; neurogenic bladder; randomized controlled trial; spinal cord injury; transcutaneous electrical stimulation; TIBIAL NERVE-STIMULATION; URINARY-TRACT DYSFUNCTION; OVERACTIVE BLADDER; POSTERIOR; NEUROSTIMULATION; NEUROMODULATION;

D O I：

10.1111/ner.13459

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objectives To assess the efficacy of transcutaneous electrical nerve stimulation (TENS) for neurogenic bladder dysfunction secondary to spinal cord injury (SCI). Materials and Methods A systematic search of MEDLINE, EMBASE, Web of Science, Scopus, and Cochrane libraries up to February 2021 was performed using PRISMA methodology. All randomized controlled trials (RCTs) that studied TENS for neurogenic bladder in a SCI population were included. The primary outcomes of interest were maximum cystometric capacity (MCC) and maximum detrusor pressure (Pdet). Meta-analysis was conducted with RevMan v5.3. Results Six RCTs involving 353 participants were included. Meta-analysis showed that TENS significantly increased MCC (standardized mean difference 1.11, 95% confidence interval [CI] 0.08-2.14, p = 0.03, I-2 = 54%) in acute SCI. No benefits were seen for maximum Pdet. TENS was associated with no major adverse events. Conclusions TENS may be an effective, safe intervention for neurogenic bladder dysfunction following SCI. Further studies are essential to confirm these results and more work is required to determine optimal stimulation parameters and duration of the treatment.

引用

页码：1237 / 1246

页数：10

共 46 条

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