RNAi screens to identify components of gene networks that modulate aging in Caenorhabditis elegans

被引：18
作者：
Ni, Zhuoyu [1 ]
Lee, Siu Sylvia [1 ]
机构：
[1] Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA
来源：
BRIEFINGS IN FUNCTIONAL GENOMICS | 2010年 / 9卷 / 01期
关键词：
aging; RNAi screen; gene networks; C; elegans; lifespan; EXTENDS LIFE-SPAN; OXIDATIVE STRESS RESISTANCE; C-ELEGANS; INSULIN-RECEPTOR; DIETARY RESTRICTION; CALORIC RESTRICTION; HUMAN LONGEVITY; DAUER FORMATION; FAMILY-MEMBER; DAF-16;
D O I：
10.1093/bfgp/elp051
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Our understanding of the genetic mechanisms of organismal aging has advanced dramatically during the past two decades. With the development of large-scale RNAi screens, the last few years saw the remarkable identifications of hundreds of new longevity genes in the roundworm Caenorhabditis elegans. The various RNAi screens revealed many biological pathways previously unknown to be related to aging. In this review, we focus on findings from the recent large-scale RNAi longevity screens, and discuss insights they have provided into the complex biological process of aging and considerations of the RNAi technology will continue to have on the future development of the aging field.
引用
收藏
页码：53 / 64
页数：12
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