Evaluation of genotoxic potential of synthetic progestin chlormadinone acetate

被引：14

作者：

Siddique, YH ^{[1
]}

Afzal, M ^{[1
]}

机构：

[1] Aligarh Muslim Univ, Fac Life Sci, Dept Zool, Genet Sect, Aligarh 202002, Uttar Pradesh, India

来源：

TOXICOLOGY LETTERS | 2004年 / 153卷 / 02期

关键词：

chlormadinone acetate; chromosomal aberrations; mouse bone marrow cells; sister chromatid exchanges; genotoxicity;

D O I：

10.1016/j.toxlet.2004.03.026

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The genotoxicity study of a synthetic progestin chlormadinone acetate, was carried out on mouse bone marrow cells using sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) as parameter, chlormadinone acetate was studied at three different doses, i.e. 5.62, 11.25 and 22.50 mg/kg body weight and was found to be non-genotoxic at 5.62 mg/kg body weight. But at 11.25 and 22.50 mg/kg of body weight chlormadinone acetate increases SCE (P < 0.001) and CA (P < 0.01) at si2nificant level compared to normal control. The results suggests a genotoxic and cytotoxic effect of chlormadinone acetate in mouse bone marrow cells. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：221 / 225

页数：5

共 27 条

[1] Evaluation of genotoxic potential of synthetic progestins-norethindrone and norgestrel in human lymphocytes in vitro [J].