iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL

被引：1237

作者：

Hallek, Michael ^{[1
,2
]}

Cheson, Bruce D. ^{[3
]}

Catovsky, Daniel ^{[4
]}

Caligaris-Cappio, Federico ^{[5
]}

Dighiero, Guillermo ^{[6
]}

Doehner, Hartmut ^{[7
]}

Hillmen, Peter ^{[8
]}

Keating, Michael ^{[9
]}

Montserrat, Emili ^{[10
]}

Chiorazzi, Nicholas ^{[11
]}

Stilgenbauer, Stephan ^{[7
]}

Rai, Kanti R. ^{[11
]}

Byrd, John C. ^{[12
]}

Eichhorst, Barbara ^{[1
]}

O'Brien, Susan ^{[13
]}

Robak, Tadeusz ^{[14
]}

Seymour, John F. ^{[15
,16
]}

Kipps, Thomas J. ^{[17
]}

机构：

[1] Univ Cologne, Klin Innere Med 1, Joseph Stelzmann Str 9, D-50924 Cologne, Germany

[2] Ctr Excellence Cellular Stress Responses Aging As, Cologne, Germany

[3] Georgetown Univ Hosp, Lombardi Canc Ctr, Washington, DC 20007 USA

[4] Inst Canc Res, London, England

[5] Univ Vita Salute San Raffaele, Dept Oncohematol, Milan, Italy

[6] Inst Pasteur, Montevideo, Uruguay

[7] Univ Ulm, Dept Internal Med 3, Ulm, Germany

[8] St Jamess Inst Oncol, Leeds, W Yorkshire, England

[9] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA

[10] Univ Barcelona, Hosp Clin, Barcelona, Spain

[11] Feinstein Inst Med Res, Manhasset, NY USA

[12] Ohio State Univ, Div Hematol, Columbus, OH 43210 USA

[13] Univ Calif Irvine, Sch Med, Div Hematol Oncol, Irvine, CA 92717 USA

[14] Med Univ Lodz, Dept Hematol, Lodz, Poland

[15] Royal Melbourne Hosp, Peter MacCallum Canc Ctr, Melbourne, Vic, Australia

[16] Univ Melbourne, Melbourne, Vic, Australia

[17] Univ Calif San Diego, Rebecca & John Moores Canc Ctr, La Jolla, CA 92093 USA

来源：

BLOOD | 2018年 / 131卷 / 25期

关键词：

CHRONIC LYMPHOCYTIC-LEUKEMIA; MINIMAL RESIDUAL DISEASE; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; STEM-CELL TRANSPLANTATION; SPONSORED-WORKING-GROUP; TUMOR LYSIS SYNDROME; QUALITY-OF-LIFE; INTERNATIONAL PROGNOSTIC INDEX; MULTIVARIATE SURVIVAL ANALYSIS; PREVIOUSLY UNTREATED PATIENTS;

D O I：

10.1182/blood-2017-09-806398

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The previous edition of the consensus guidelines of the International Workshop on Chronic Lymphocytic Leukemia (iwCLL), published in 2008, has found broad acceptance by physicians and investigators caring for patients with CLL. Recent advances including the discovery of the genomic landscape of the disease, the development of genetic tests with prognostic relevance, and the detection of minimal residual disease (MRD), coupled with the increased availability of novel targeted agents with impressive efficacy, prompted an international panel to provide updated evidence- and expert opinion-based recommendations. These recommendations include a revised version of the iwCLL response criteria, an update on the use of MRD status for clinical evaluation, and recommendations regarding the assessment and prophylaxis of viral diseases during management of CLL.

引用

页码：2745 / 2760

页数：16

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