Supercritical Foaming and Impregnation of Polycaprolactone and Polycaprolactone-Hydroxyapatite Composites with Carvacrol

被引:8
作者
Satpayeva, Alina [1 ,2 ]
Rojas, Adrian [3 ,4 ]
Tyrka, Marcin [5 ]
Ksepko, Ewelina [5 ]
Jose Galotto, Maria [3 ,4 ]
Zizovic, Irena [5 ]
机构
[1] Aix Marseille Univ, Fac Sci, F-13013 Marseille, France
[2] Univ Valladolid, Dept Chem Engn & Environm Technol, High Pressure Proc Grp, Valladolid 47011, Spain
[3] Univ Santiago Chile USACH, Fac Technol, Packaging Innovat Ctr LABEN, Dept Sci & Food Technol, Santiago 9170201, Chile
[4] Ctr Dev Nanosci & Nanotechnol CEDENNA, Santiago 9170124, Chile
[5] Wroclaw Univ Sci & Technol, Fac Chem, PL-50370 Wroclaw, Poland
关键词
supercritical CO2; polycaprolactone; hydroxyapatite; scaffold; foaming; impregnation; carvacrol; CARBON-DIOXIDE; CELLULOSE-ACETATE; POROUS SCAFFOLD; CO2; PCL; THYMOL; POLY(EPSILON-CAPROLACTONE); FABRICATION; POLYMERS; DELIVERY;
D O I
10.3390/pr10030482
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
Polycaprolactone (PCL) and polycaprolactone-hydroxyapatite (PCL-HA) scaffolds were produced by foaming in supercritical carbon dioxide (scCO(2)) at 20 MPa, as well as in one-step foaming and impregnation process using carvacrol as an antibacterial agent with proven activity against Gram-positive and Gram-negative bacteria. The experimental design was developed to study the influence of temperature (40 degrees C and 50 degrees C), HA content (10 and 20 wt.%), and depressurization rate (one and two-step decompression) on the foams' morphology, porosity, pore size distribution, and carvacrol impregnation yield. The characterization of the foams was carried out using scanning electron microscopy (SEM, SEM-FIB), Gay-Lussac density bottle measurements, and Fourier-transform infrared (FTIR) analyses. The obtained results demonstrate that processing PCL and PCL-HA scaffolds by means of scCO(2) foaming enables preparing foams with porosity in the range of 65.55-74.39% and 61.98-67.13%, at 40 degrees C and 50 degrees C, respectively. The presence of carvacrol led to a lower porosity. At 40 degrees C and one-step decompression at a slow rate, the porosity of impregnated scaffolds was higher than at 50 degrees C and two- step fast decompression. However, a narrower pore size distribution was obtained at the last processing conditions. PCL scaffolds with HA resulted in higher carvacrol impregnation yields than neat PCL foams. The highest carvacrol loading (10.57%) was observed in the scaffold with 10 wt.% HA obtained at 50 degrees C.
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页数:20
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