Pomegranate and breast cancer: possible mechanisms of prevention

被引：48

作者：

Sturgeon, Susan R. ^{[1
]}

Ronnenberg, Alayne G. ^{[2
]}

机构：

[1] Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Dept Publ Hlth, Amherst, MA 01003 USA

[2] Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Dept Nutr, Amherst, MA 01003 USA

来源：

NUTRITION REVIEWS | 2010年 / 68卷 / 02期

关键词：

breast cancer; ellagitannins; estrogen; pomegranate juice; DIETARY FLAVONOID INTAKE; PUNICA-GRANATUM L; POSTMENOPAUSAL WOMEN; ELLAGIC ACID; ELLAGITANNIN METABOLITES; MASS-SPECTROMETRY; SEED OIL; RISK; ESTROGEN; JUICE;

D O I：

10.1111/j.1753-4887.2009.00268.x

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Several mechanistic studies in cell culture and mouse models suggest possible estrogen receptor-mediated and non-estrogen receptor-mediated benefits of pomegranate juice with respect to breast cancer risk. These studies demonstrate that various constituents of pomegranates can inhibit aromatase and 17 beta-hydroxysteroid dehydrogenase enzymes or have antiestrogenic activity. Additional large, well-controlled human studies are warranted to elucidate the effects of pomegranate juice intake on serum hormone levels. Clarifying the effects of pomegranate constituents on key hormones known to be involved in breast cancer could result in important information for consumers and shed further light on the impact of diet on breast cancer risk. (C) 2010 International Life Sciences Institute

引用

页码：122 / 128

页数：7

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