Lipoic Acid Decreases the Viability of Breast Cancer Cells and Activity of PTP1B and SHP2

被引：29

作者：

Kuban-Jankowska, Alicja ^{[1
]}

Gorska-Ponikowska, Magdalena ^{[1
]}

Wozniak, Michal ^{[1
]}

机构：

[1] Med Univ Gdansk, Dept Med Chem, Debinki 1, PL-80210 Gdansk, Poland

来源：

ANTICANCER RESEARCH | 2017年 / 37卷 / 06期

关键词：

Breast cancer; lipoic acid; ALA; DHLA; PTP1B; SHP2; PROTEIN-TYROSINE PHOSPHATASES; IN-VITRO; CHEMOTHERAPY; ANTIOXIDANT; CONTRIBUTES; NEUROPATHY; COLON;

D O I：

10.21873/anticanres.11642

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Protein tyrosine phosphatases PTP1B and SHP2 are potential targets for anticancer therapy, because of the essential role they play in the development of tumors. PTP1B and SHP2 are overexpressed in breast cancer cells, thus inhibition of their activity can be potentially effective in breast cancer therapy. Lipoic acid has been previously reported to inhibit the proliferation of colon, breast and thyroid cancer cells. Materials and Methods: We investigated the effect of alpha-lipoic acid (ALA) and its reduced form of dihydrolipoic acid (DHLA) on the viability of MCF-7 cancer cells and on the enzymatic activity of PTP1B and SHP2 phosphatases. Results: ALA and DHLA decrease the activity of PTP1B and SHP2, and have inhibitory effects on the viability and proliferation of breast cancer cells. Conclusion: ALA and DHLA can be considered as potential agents for the adjunctive treatment of breast cancer.

引用

页码：2893 / 2898

页数：6

共 24 条

[1]

Aceto N, 2012, ONCOTARGET, V3, P514

[2] Antileukemic effects of piperlongumine and alpha lipoic acid combination on Jurkat, MEC1 and NB4 cells in vitro [J].

Alpay, Merve ;

Yurdakok-Dikmen, Begum ;

Kismali, Gorkem ;

Sel, Tevhide .

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2016, 12 (02) :556-560

[3] Epithelial Protein-Tyrosine Phosphatase 1B Contributes to the Induction of Mammary Tumors by HER2/Neu but Is Not Essential for Tumor Maintenance [J].

Balavenkatraman, Kamal K. ;

Aceto, Nicola ;

Britschgi, Adrian ;

Mueller, Urs ;

Bence, Kendra K. ;

Neel, Benjamin G. ;

Bentires-Alj, Mohamed .

MOLECULAR CANCER RESEARCH, 2011, 9 (10) :1377-1384

[4] Neuronal PTP1B regulates body weight, adiposity and leptin action [J].

Bence, Kendra K. ;

Delibegovic, Mirela ;

Xue, Bingzhong ;

Gorgun, Cem Z. ;

Hotamisligil, Gokhan S. ;

Neel, Benjamin G. ;

Kahn, Barbara B. .

NATURE MEDICINE, 2006, 12 (08) :917-924

[5] The pharmacology of the antioxidant lipoic acid [J].

Biewenga, GP ;

Haenen, GRMM ;

Bast, A .

GENERAL PHARMACOLOGY, 1997, 29 (03) :315-331

[6] Lipoic acid and lipoic acid analogs in cancer metabolism and chemotherapy [J].

Bingham, Paul M. ;

Stuart, Shawn D. ;

Zachar, Zuzana .

EXPERT REVIEW OF CLINICAL PHARMACOLOGY, 2014, 7 (06) :837-846

[7] Parthenolide and DMAPT exert cytotoxic effects on breast cancer stem-like cells by inducing oxidative stress, mitochondrial dysfunction and necrosis [J].

Carlisi, D. ;

Buttitta, G. ;

Di Fiore, R. ;

Scerri, C. ;

Drago-Ferrante, R. ;

Vento, R. ;

Tesoriere, G. .

CELL DEATH & DISEASE, 2016, 7 :e2194-e2194

[8] Chemopreventive potential of alpha lipoic acid in the treatment of colon and cervix cancer cell lines [J].

Damnjanovic, I ;

Kocic, G. ;

Najman, S. ;

Stojanovic, S. ;

Stojanovic, D. ;

Veljkovic, A. ;

Conic, I ;

Langerholc, T. ;

Pesic, S. .

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, 2014, 115 (10) :611-616

[9] Use of an alpha lipoic, methylsulfonylmethane and bromelain dietary supplement (Opera®) for chemotherapy-induced peripheral neuropathy management, a prospective study [J].

Desideri, Isacco ;

Francolini, Giulio ;

Becherini, Carlotta ;

Terziani, Francesca ;

Paoli, Camilla Delli ;

Olmetto, Emanuela ;

Loi, Mauro ;

Perna, Marco ;

Meattini, Icro ;

Scotti, Vieri ;

Greto, Daniela ;

Bonomo, Pierluigi ;

Sulprizio, Susanna ;

Livi, Lorenzo .

MEDICAL ONCOLOGY, 2017, 34 (03)

[10] Lipoic acid inhibits cell proliferation of tumor cells in vitro and in vivo [J].

Feuerecker, Benedikt ;

Pirsig, Sabine ;

Seidl, Christof ;

Aichler, Michaela ;

Feuchtinger, Annette ;

Bruchelt, Gernot ;

Senekowitsch-Schmidtke, Reingard .

CANCER BIOLOGY & THERAPY, 2012, 13 (14) :1425-1435

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