Major bleeding with old and novel oral anticoagulants: How tomanage it. Focus on general measures

被引：7

作者：

Di Fusco, Stefania Angela ^{[1
,9
]}

Luca, Fabiana ^{[2
,9
]}

Benvenuto, Manuela ^{[3
,9
]}

Iorio, Annamaria ^{[4
]}

Fiscella, Damiana ^{[5
,9
]}

D'Ascenzo, Fabrizio ^{[6
,9
]}

Madeo, Andrea ^{[7
,9
]}

Colivicchi, Furio ^{[1
]}

Di Lenarda, Andrea ^{[8
,10
]}

Gulizia, Michele Massimo ^{[5
,9
]}

机构：

[1] San Filippo Neri Hosp, Cardiol Unit, Via Martinotti 20, I-00135 Rome, Italy

[2] Big Metropolitan Hosp Melacrino Morelli, Cardiol Dept, Reggio Di Calabria, Italy

[3] Augusto Murri Hosp, Cardiol Unit, Fermo, Italy

[4] Papa Giovanni XXIII Hosp, Cardiol Dept, Bergamo, Italy

[5] Azienda Rilevo Nazl & Alta Specialita, Osped Garibaldi Nesima, Cardiol Dept, Catania, Italy

[6] Univ Turin, Citta Salute & Sci, Dept Internal Med, Div Cardiol, Turin, Italy

[7] San Camillo Forlanini Hosp, Cardiol Dept, Rome, Italy

[8] Trieste Hosp, Cardiovasc Ctr, Trieste, Italy

[9] Area Giovani ANMCO, Florence, Italy

[10] ANMCO Board, Florence, Italy

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2018年 / 268卷

关键词：

Major bleeding; Non-vitamin K antagonist oral anticoagulants; Vitamin-K antagonists; Warfarin; HEART RHYTHM ASSOCIATION; ATRIAL-FIBRILLATION; DABIGATRAN ETEXILATE; PRACTICAL GUIDE; WARFARIN; MANAGEMENT; APIXABAN; EDOXABAN; SAFETY; RISK;

D O I：

10.1016/j.ijcard.2018.05.061

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

has changed the therapeutic landscape in the prevention of thromboembolic events. Although NOACs compared to vitamin K antagonists (VKAs) have demonstrated a similar or slightly lower rate of major bleeding and a lower rate of intracranial or fatal bleeding, hemorrhaging still represents the main adverse effect of anticoagulant treatment. This review reports data on the rates of major bleeding with old and new oral anticoagulants. It analyses laboratory tests that can be used to assess the intensity of anticoagulation in patients treated with oral anticoagulants and discusses general measures to implement in managing major bleeding. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：80 / 84

页数：5

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