Mild and efficient syntheses of diverse isoindolinones from ortho-phthaldehydic acid methylthiomethyl ester

被引：32

作者：

Ghosh, Usha ^{[1
]}

Bhattacharyya, Rituparna ^{[1
]}

Keche, Ashish ^{[1
]}

机构：

[1] Piramal Life Sci Ltd, Bombay 400063, Maharashtra, India

来源：

TETRAHEDRON | 2010年 / 66卷 / 12期

关键词：

Isoindolinones; Reductive amination; Methylthiomethyl ester; Lactamization; CATALYZED CARBONYLATIVE CYCLIZATION; DIELS-ALDER REACTIONS; FUNCTIONALIZED ISOINDOLINONES; ASYMMETRIC-SYNTHESIS; POTENT INHIBITORS; DERIVATIVES; ISOINDOLIN-1-ONES; AUXILIARIES; ALKALOIDS; LIGANDS;

D O I：

10.1016/j.tet.2010.01.070

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and efficient method for the synthesis of diverse isoindolinones from o-phthaldehydic acid methylthiomethyl ester and aliphatic/aromatic amines has been developed A number of nucleophiles Including a hydride ion were Successfully added to the intermediate Schiff's base providing iso-indolinones. with or Without substitution at 3-position Conditions have also been developed for amines with an integrated nucleophilic group to react in a diverse fashion either to give isoindolinones or tricyclic gamma-lactams as single diastereoisomers in very good yield (C) 2010 Elsevier Ltd All rights reserved

引用

页码：2148 / 2155

页数：8

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