Heme oxygenase-1: A fundamental guardian against oxidative tissue injuries in acute inflammation

被引：0

作者：

Takahashi, T.

Shimizu, H.

Morimatsu, H.

Inoue, K.

Akagi, R.

Morita, K.

Sassa, S.

机构：

[1] Okayama Univ, Sch Med, Dept Anesthesiol & Resuscitol, Okayama 7708558, Japan

[2] Okayama Prefectural Univ, Dept Nutr Sci, Soja, Japan

[3] Rockefeller Univ, New York, NY 10021 USA

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2007年 / 7卷 / 07期

关键词：

carbon monoxide; heme; heme oxygenase-1; inflammation; liver injury; oxidative stress; renal injury; sepsis;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Free heme contributes as a major threat to the oxidative tissue injuries because it catalyzes the formation of reactive oxygen species. When free heme concentration is increased, it results in the induction of heme oxygenase-1 (1401), which then breaks free heme down. As such, HO-1 plays a pivotal role in the protection of tissues from oxidative injuries.

引用

收藏

页码：745 / 753

页数：9

相关论文

共 112 条

[1] Fundamental role of heme oxygenase in the protection against ischemic acute renal failure [J].

Akagi, R ;

Takahashi, T ;

Sassa, S .

JAPANESE JOURNAL OF PHARMACOLOGY, 2002, 88 (02) :127-132

[2] Heme activates the heme oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2 [J].

Alam, J ;

Killeen, E ;

Gong, PF ;

Naquin, R ;

Hu, B ;

Stewart, D ;

Ingelfinger, JR ;

Nath, KA .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2003, 284 (04) :F743-F752

[3] Increase in exhaled carbon monoxide during exacerbations of cystic fibrosis [J].

Antuni, JD ;

Kharitonov, SA ;

Hughes, D ;

Hodson, ME ;

Barnes, PJ .

THORAX, 2000, 55 (02) :138-142

[4] METABOLIC REGULATION OF HEME CATABOLISM AND BILIRUBIN PRODUCTION .1. HORMONAL-CONTROL OF HEPATIC HEME OXYGENASE ACTIVITY [J].

BAKKEN, AF ;

SCHMID, R ;

THALER, MM .

JOURNAL OF CLINICAL INVESTIGATION, 1972, 51 (03) :530-&

[5] Biliverdin reductase:: A major physiologic cytoprotectant [J].

Barañano, DE ;

Rao, M ;

Ferris, CD ;

Snyder, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (25) :16093-16098

[6] Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis [J].

Brouard, S ;

Otterbein, LE ;

Anrather, J ;

Tobiasch, E ;

Bach, FH ;

Choi, AMK ;

Soares, MP .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (07) :1015-1025

[7] INDUCTION OF HEME OXYGENASE-1 GENE-EXPRESSION BY LIPOPOLYSACCHARIDE IS MEDIATED BY AP-1 ACTIVATION [J].

CAMHI, SL ;

ALAM, J ;

OTTERBEIN, L ;

SYLVESTER, SL ;

CHOI, AMK .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1995, 13 (04) :387-398

[8] Transcriptional activation of the H0-1 gene by lipopolysaccharide is mediated by 5′ distal enhancers:: Role of reactive oxygen intermediates and AP-1 [J].

Camhi, SL ;

Alam, J ;

Wiegand, GW ;

Chin, BY ;

Choi, AMK .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1998, 18 (02) :226-234

[9] Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: Effect of chemical structure and stress signals [J].

Chen, C ;

Pung, D ;

Leong, V ;

Hebbar, V ;

Shen, GX ;

Nair, S ;

Li, W ;

Kong, ANT .

FREE RADICAL BIOLOGY AND MEDICINE, 2004, 37 (10) :1578-1590

[10] Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma [J].

Chesi, M ;

Bergsagel, PL ;

Shonukan, OO ;

Martelli, ML ;

Brents, LA ;

Chen, T ;

Schröck, E ;

Ried, T ;

Kuehl, VM .

BLOOD, 1998, 91 (12) :4457-4463

← 1 2 3 4 5 6 7 8 9 10 →