Biomarkers of inflammation and oxidative stress in atherosclerosis

被引：52

作者：

Uno, Kiyoko ^{[1
]}

Nicholls, Stephen J. ^{[1
]}

机构：

[1] Cleveland Clin, Dept Cardiovasc Med, Inst Heart & Vasc, Cleveland, OH 44195 USA

来源：

BIOMARKERS IN MEDICINE | 2010年 / 4卷 / 03期

关键词：

atherosclerosis; inflammation; oxidative stress; LOW-DENSITY-LIPOPROTEIN; C-REACTIVE PROTEIN; INTIMA-MEDIA THICKNESS; CORONARY-HEART-DISEASE; MYELOPEROXIDASE-CATALYZED OXIDATION; ASYMMETRIC DIMETHYLARGININE ADMA; CIRCULATING OXIDIZED LDL; HUMAN ENDOTHELIAL-CELLS; SOLUBLE CD40 LIGAND; NITRIC-OXIDE;

D O I：

10.2217/BMM.10.57

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Increasing evidence has highlighted the roles of oxidative stress and inflammation in the promotion of atherosclerotic cardiovascular disease. Recent pathological studies have elucidated specific: mediators that appear to link these pathways to the progression and rupture of atherosclerotic plaque in the artery wall. The ability to measure levels of these mediators in the systemic circulation has provoked interest in their development as biomarkers for potential use in risk assessment and in evaluation of the response to the use of preventive therapies. The discovery of these pathological mediators and their potential translation to the clinical arena will be reviewed.

引用

页码：361 / 373

页数：13

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