Analysis of anti-depressant potential of curcumin against depression induced male albino wistar rats

被引：32

作者：

Chang, Xue-run ^{[1
]}

Wang, Li ^{[2
]}

Li, Jing ^{[3
]}

Wu, Dian-shui ^{[4
]}

机构：

[1] Shandong Mental Hlth Ctr, Lab Med, Jinan 250014, Shandong, Peoples R China

[2] Shandong Univ, Jinan Infect Dis Hosp, Lab Med, 22029 Jingshi Rd, Jinan 250021, Shandong, Peoples R China

[3] Shandong Blood Ctr, Blood Grp Reference Lab, Jinan 250014, Shandong, Peoples R China

[4] Shandong Univ, Shangdong Prov Hosp, Lab Med, Jinan 250022, Shandong, Peoples R China

来源：

BRAIN RESEARCH | 2016年 / 1642卷

关键词：

Curcumin; Rats; Dopamine; Swim test; Noradrenaline; OLFACTORY BULBECTOMIZED RAT; MODEL; ANTIOXIDANT; DESIPRAMINE; CELLS; ZINC;

D O I：

10.1016/j.brainres.2016.03.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study investigated the antidepressant potential of curcumin in olfactory bulbectomy and forced swimming test models of depression in male albino rats under chronic treatment. The experimental animals were divided into four groups, and curcumin was administered for 45 days. Our results showed that the curcumin significantly reduced olfactory bulbectomy-induced behavioral abnormalities including deficits in step-down passive avoidance, increased activity in the open area and immobility time. Chronic administration of curcumin significantly reversed levels of 3, 4-dihydroxyphenylacetic acid, noradrenaline, serotonin and 5-hydroxyindoleacetic acid in the hippocampus region of male albino rats. Also, curcumin normalizes the levels of dopamine, noradrenaline, and 5-hydroxyindoleacetic acid in the frontal cortex of rats. Taking all these results together, it may suggest that curcumin is potent compound acting against the depression in the male albino rats. (C) 2016 Published by Elsevier B.V.

引用

页码：219 / 225

页数：7

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