ELECTROSPUN SODIUM ALGINATE/POLY(ETHYLENE OXIDE) NANOFIBERS FOR WOUND HEALING APPLICATIONS: CHALLENGES AND FUTURE DIRECTIONS

被引：13

作者：

Al-Moalemi, Hafedh Ahmed ^{[1
]}

Abd Razak, Saiful Izwan ^{[2
]}

Bohari, Siti Pauliena Mohd ^{[1
,3
]}

机构：

[1] Univ Teknol Malaysia, Fac Sci, Dept Biosci, Skudai 81310, Johor, Malaysia

[2] Univ Teknol Malaysia, Fac Engn, Sch Biomed Engn & Hlth Sci, BioInspired Device & Tissue Engn Res Grp, Skudai 81300, Johor, Malaysia

[3] Univ Teknol Malaysia, Inst Bioprod Dev, Cosmet & Fragrance Lab, Johor Baharu, Malaysia

来源：

CELLULOSE CHEMISTRY AND TECHNOLOGY | 2022年 / 56卷 / 3-4期

关键词：

sodium alginate; poly(ethylene oxide); electrospinning; wound healing; POLY(ETHYLENE OXIDE); DRUG-DELIVERY; POLYETHYLENE OXIDE; CONTROLLED-RELEASE; BLEND NANOFIBERS; POLYMER NANOFIBERS; GROWTH-FACTOR; ALGINATE; DRESSINGS; FIBERS;

D O I：

10.35812/CelluloseChemTechnol.2022.56.23

中图分类号：

TB3 [工程材料学]; TS [轻工业、手工业、生活服务业];

学科分类号：

0805 ; 080502 ; 0822 ;

摘要：

Alginate is an interesting natural biopolymer to be considered for biomedical applications due to its advantages and good biological properties. These biological properties make electrospun alginate nanofibers suitable for various uses in the biomedical field, such as wound healing dressings, drug delivery systems, or both. Unfortunately, the fabrication of alginate nanofibers by electrospinning is very challenging because of the high viscosity of the solution, high surface tension and rigidity in water due to hydrogen bonding, and also their diaxial linkages. This review presents an overview of the factors affecting the electrospinning process of sodium alginate/poly(ethylene oxide) (SA/PEO), the application of SA/PEO in drug delivery systems for wound healing applications, and the degradation and swelling properties of SA/PEO. The challenges and future directions of SA/PEO in the medical field are also discussed.

引用

页码：251 / 270

页数：20

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