Tyrosine Kinase Inhibitors Enhance Ciprofloxacin-Induced Phototoxicity by Inhibiting ABCG2

被引：4

作者：

Mealey, Katrina L. ^{[1
]}

Dassanayake, Sandamali ^{[1
]}

Burke, Neal S. ^{[1
]}

机构：

[1] Washington State Univ, Coll Vet Med, Dept Vet Clin Sci, Individualized Med Program, Pullman, WA 99164 USA

来源：

ONCOLOGY | 2014年 / 87卷 / 06期

关键词：

ABCG2; Fluoroquinolone; Retina; Phototoxicity; Tyrosine kinase inhibitors; PHARMACOKINETICS; FLUOROQUINOLONES; NEUTROPENIA;

D O I：

10.1159/000366132

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The tyrosine kinase inhibitor (TKI) class of anticancer agents inhibits ABCG2-mediated drug efflux. ABCG2 is an important component of the blood-retinal barrier, where it limits retinal exposure to phototoxic compounds such as fluoroquinolone antibiotics. Patients treated with TKIs would be expected to be at greater risk for retinal phototoxicity. Using an in vitro system, our results indicate that the TKIs gefitinib and imatinib abrogate the ability of ABCG2 to protect cells against ciprofloxacin-induced phototoxicity. We conclude that the concurrent administration of ABCG2 inhibitors with photoreactive fluoroquinolone antibiotics may result in retinal damage. (C) 2014 S. Karger AG, Basel

引用

页码：364 / 370

页数：7

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