Long spinal cord lesions in a patient with pathologically proven multiple sclerosis

被引：2

作者：

Komatsu, Junji ^{[1
]}

Sakai, Kenji ^{[1
]}

Nakada, Mitsutoshi ^{[2
]}

Iwasa, Kazuo ^{[1
]}

Yamada, Masahito ^{[1
]}

机构：

[1] Kanazawa Univ, Dept Neurol & Neurobiol Aging, Grad Sch Med Sci, 13-1 Takara Machi, Kanazawa, Ishikawa 9208640, Japan

[2] Kanazawa Univ Hosp, Dept Neurosurg, 13-1 Takara Machi, Kanazawa, Ishikawa 9208640, Japan

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2017年 / 42卷

关键词：

Multiple sclerosis; Longitudinally extensive spinal cord lesion; Magnetic resonance imaging; Pathology; NEUROMYELITIS-OPTICA; SPECTRUM; DISEASE;

D O I：

10.1016/j.jocn.2017.03.022

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. We report the case of a 50-year-old man who presented with progressive gait ataxia. Brain magnetic resonance imaging (MRI) on fluid-attenuated inversion recovery revealed a hyperintense lesion in the right temporal white matter. The spinal cord showed a long hyperintense lesion between the vertebral levels C6 and L1 on T2-weighted MRI. Biopsied tissues from the brain lesion demonstrated features of inflammatory demyelination with preservation of astrocytes, consistent with typical MS. This is the first reported case of pathologically proven MS with longitudinally extensive spinal cord lesions. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：106 / 108

页数：3

共 8 条

[1] Spinal cord lesions and disability in Hispanics with multiple sclerosis
Amezcua, L.
Lerner, A.
Ledezma, K.
Conti, D.
Law, M.
Weiner, L.
Langer-Gould, A.
[J]. JOURNAL OF NEUROLOGY, 2013, 260 (11) : 2770 - 2776
[2] Myelin oligodendrocyte glycoprote in-specific T and B cells cooperate to induce a Devic-like disease in mice
Bettelli, Estelle
Baeten, Dominique
Jager, Anneli
Sobel, Raymond A.
Kuchroo, Vijay K.
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (09) : 2393 - 2402
[3] Spinal cord abnormalities in recently diagnosed MS patients
Bot, JCJ
Barkhof, F
Polman, CH
Nijeholt, GJLA
de Groot, V
Bergers, E
Ader, HJ
Castelijns, JA
[J]. NEUROLOGY, 2004, 62 (02) : 226 - 233
[4] Distinctive clinical and neuroimaging characteristics of longitudinally extensive transverse myelitis associated with aquaporin-4 autoantibodies
Iorio, Raffaele
Damato, Valentina
Mirabella, Massimiliano
Evoli, Amelia
Marti, Alessandro
Plantone, Domenico
Frisullo, Giovanni
Batocchi, Anna Paola
[J]. JOURNAL OF NEUROLOGY, 2013, 260 (09) : 2396 - 2402
[5] Heterogeneity of aquaporin-4 autoimmunity and spinal cord lesions in multiple sclerosis in Japanese
Matsuoka, Takeshi
Matsushita, Takuya
Kawano, Yuji
Osoegawa, Manabu
Ochi, Hirofumi
Ishizu, Takaaki
Minohara, Motozumi
Kikuchi, Hitoshi
Mihara, Futoshi
Ohyagi, Yasumasa
Kira, Jun-ichi
[J]. BRAIN, 2007, 130 : 1206 - 1223
[6] Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definition and pathogenesis
Sato, Douglas Kazutoshi
Callegaro, Dagoberto
Lana-Peixoto, Marco Aurelio
Nakashima, Ichiro
Fujihara, Kazuo
[J]. ARQUIVOS DE NEURO-PSIQUIATRIA, 2014, 72 (06) : 445 - 450
[7] Revised diagnostic criteria for neuromyelitis optica
Wingerchuk, D. M.
Lennon, V. A.
Pittock, S. J.
Lucchinetti, C. F.
Weinshenker, B. G.
[J]. NEUROLOGY, 2006, 66 (10) : 1485 - 1489
[8] The spectrum of neuromyelitis optica
Wingerchuk, Dean M.
Lennon, Vando A.
Lucchinetti, Claudia F.
Pittock, Seanj
Weinshenker, Brian G.
[J]. LANCET NEUROLOGY, 2007, 6 (09) : 805 - 815

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