Hospitalisation and mortality in patients with comorbid COPD and heart failure: a systematic review and meta-analysis

被引:42
作者
Axson, Eleanor L. [1 ]
Ragutheeswaran, Kishan [1 ]
Sundaram, Varun [1 ]
Bloom, Chloe, I [1 ]
Bottle, Alex [2 ]
Cowie, Martin R. [1 ]
Quint, Jennifer K. [1 ]
机构
[1] Imperial Coll London, Natl Heart & Lung Inst, G05 Emmanuel Kaye Bldg,Manresa Rd, London SW3 6LR, England
[2] Imperial Coll London, Dept Primary Care & Publ Hlth, Dr Foster Unit, London, England
关键词
COPD; Heart failure; Mortality; Hospitalisation; Rehospitalisation; Systematic review; Comorbidity; OBSTRUCTIVE PULMONARY-DISEASE; ACUTE EXACERBATIONS; CARDIOVASCULAR COMORBIDITY; RISK; PREDICTORS; IMPACT; OUTCOMES; COSTS; READMISSION; MANAGEMENT;
D O I
10.1186/s12931-020-1312-7
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Background Discrepancy exists amongst studies investigating the effect of comorbid heart failure (HF) on the morbidity and mortality of chronic obstructive pulmonary disease (COPD) patients. Methods MEDLINE and Embase were searched using a pre-specified search strategy for studies comparing hospitalisation, rehospitalisation, and mortality of COPD patients with and without HF. Studies must have reported crude and/or adjusted rate ratios, risk ratios, odds ratios (OR), or hazard ratios (HR). Results Twenty-eight publications, reporting 55 effect estimates, were identified that compared COPD patients with HF with those without HF. One study reported on all-cause hospitalisation (1 rate ratio). Two studies reported on COPD-related hospitalisation (1 rate ratio, 2 OR). One study reported on COPD- or cardiovascular-related hospitalisation (4 HR). One study reported on 90-day all-cause rehospitalisation (1 risk ratio). One study reported on 3-year all-cause rehospitalisation (2 HR). Four studies reported on 30-day COPD-related rehospitalisation (1 risk ratio; 5 OR). Two studies reported on 1-year COPD-related rehospitalisation (1 risk ratio; 1 HR). One study reported on 3-year COPD-related rehospitalisation (2 HR). Eighteen studies reported on all-cause mortality (1 risk ratio; 4 OR; 24 HR). Five studies reported on all-cause inpatient mortality (1 risk ratio; 4 OR). Meta-analyses of hospitalisation and rehospitalisation were not possible due to insufficient data for all individual effect measures. Meta-analysis of studies requiring spirometry for the diagnosis of COPD found that risk of all-cause mortality was 1.61 (pooled HR; 95%CI: 1.38, 1.83) higher in patients with HF than in those without HF. Conclusions In this systematic review, we investigated the effect of HF comorbidity on hospitalisation and mortality of COPD patients. There is substantial evidence that HF comorbidity increases COPD-related rehospitalisation and all-cause mortality of COPD patients. The effect of HF comorbidity may differ depending on COPD phenotype, HF type, or HF severity and should be the topic of future research.
引用
收藏
页数:13
相关论文
共 58 条
[1]   Chronic obstructive pulmonary disease mortality, a competing risk analysis [J].
Abukhalaf, Jawad ;
Davidson, Ross ;
Villalobos, Nicolas ;
Meek, Paula ;
Petersen, Hans ;
Sood, Akshay ;
Tesfaigzi, Yohannes ;
Guillamet, Rodrigo Vazquez .
CLINICAL RESPIRATORY JOURNAL, 2018, 12 (11) :2598-2605
[2]   Independent Risk Factors for Mortality in Patients with Chronic Obstructive Pulmonary Disease Who Undergo Comprehensive Cardiac Evaluations [J].
Ahn, Young-Hwan ;
Lee, Keu Sung ;
Park, Joo Hun ;
Jung, Jin-Hee ;
Lee, Miyeon ;
Jung, Yun-Jung ;
Chung, Wou Young ;
Sheen, Seungsoo ;
Park, Kwang Joo ;
Kim, Dae Jung ;
Kang, Dae Ryoung ;
Lee, Jeong-Dong ;
Yoon, Soojee ;
Jin, Xiong Jie ;
Yang, Hyoung-Mo ;
Lim, Hong-Seok ;
Park, Jin Sun ;
Shin, Joon-Han ;
Tahk, Seung-Jea .
RESPIRATION, 2015, 90 (03) :199-205
[3]   Comorbidities and Short-term Prognosis in Patients Hospitalized for Acute Exacerbation of COPD The EPOC en Servicios de Medicina Interna (ESMI) Study [J].
Almagro, Pedro ;
Javier Cabrera, Francisco ;
Diez, Jesus ;
Boixeda, Ramon ;
Alonso Ortiz, M. Belen ;
Murio, Cristina ;
Soriano, Joan B. .
CHEST, 2012, 142 (05) :1126-1133
[4]  
[Anonymous], EUR J HEART FAIL
[5]  
[Anonymous], AM J RESP CRIT CARE
[6]   Hospitalisation and mortality outcomes of patients with comorbid COPD and heart failure: a systematic review protocol [J].
Axson, Eleanor L. ;
Sundaram, Varun ;
Bloom, Chloe I. ;
Bottle, Alex ;
Cowie, Martin R. ;
Quint, Jennifer K. .
BMJ OPEN, 2018, 8 (06)
[7]  
Bakke PS, 2013, EUR RESPIR MONOGR, P217, DOI 10.1183/1025448x.10012612
[8]  
Belloli EA, 2011, AM J RESP CRIT CARE, V183
[9]   Cardiovascular disease in COPD: a call for action [J].
Bhatt, Surya P. ;
Wells, J. Michael ;
Dransfield, Mark T. .
LANCET RESPIRATORY MEDICINE, 2014, 2 (10) :783-785
[10]   The impact of concurrent heart failure on prognosis in patients with chronic obstructive pulmonary disease [J].
Boudestein, Laura C. M. ;
Rutten, Frans H. ;
Cramer, Maarten J. ;
Lammers, Jan Willem J. ;
Hoes, Arno W. .
EUROPEAN JOURNAL OF HEART FAILURE, 2009, 11 (12) :1182-1188