Core-Shell-Type Magnetic Mesoporous Silica Nanocomposites for Bioimaging and Therapeutic Agent Delivery

被引：224
作者：
Wang, Yao [1 ,2 ]
Gu, Hongchen [1 ,2 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Biomed Engn, State Key Lab Oncogenes & Related Genes, Shanghai 200030, Peoples R China
[2] Shanghai Jiao Tong Univ, Med X Res Inst, Shanghai 200030, Peoples R China
来源：
ADVANCED MATERIALS | 2015年 / 27卷 / 03期
关键词：
IRON-OXIDE NANOPARTICLES; DRUG-DELIVERY; SIRNA DELIVERY; THERANOSTIC APPLICATIONS; CONTROLLED RELEASE; TARGETED DELIVERY; RNA INTERFERENCE; CONTRAST AGENTS; CANCER-THERAPY; SPHERES;
D O I：
10.1002/adma.201401124
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Advances in nanotechnology and nanomedicine offer great opportunities for the development of nanoscaled theranostic platforms. Among various multifunctional nanocarriers, magnetic mesoporous silica nanocomposites (M-MSNs) attract prominent research interest for their outstanding properties and potential biomedical applications. This Research News article highlights recent progress in the design of core-shell-type M-MSNs for both diagnostic and therapeutic applications. First, an overview of synthetic strategies for three representative core-shell-type M-MSNs with different morphologies and structures is presented. Then, the diagnostic functions of M-MSNs is illustrated for magnetic resonance imaging (MRI) applications. Next, magnetic targeted delivery and stimuli-responsive release of drugs, and effective package of DNA/siRNA inside mesopores using M-MSNs as therapeutic agent carriers are discussed. The article concludes with some import ant challenges that need to be overcome for further practical applications of M-MSNs in nanomedicine.
引用
收藏
页码：576 / 585
页数：10
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