Successful Mesenchymal Stem Cell Application in Supraventricular Tachycardia-Related Necrotizing Enterocolitis: A Case Report

被引:23
|
作者
Akduman, Hasan [1 ]
Dilli, Dilek [1 ]
Ergun, Ergun [2 ]
Cakmakci, Emin [3 ]
Celebi, Serpil Kaya [4 ]
Citli, Rumeysa [1 ]
Zenciroglu, Aysegul [1 ]
机构
[1] Univ Hlth Sci, Dr Sami Ulus Gynecol Obstet & Child Hlth & Dis Tr, Dept Neonatol, TR-06080 Ankara, Turkey
[2] Univ Hlth Sci, Dr Sami Ulus Gynecol Obstet & Child Hlth & Dis Tr, Dept Pediat Surg, Ankara, Turkey
[3] Univ Hlth Sci, Dr Sami Ulus Gynecol Obstet & Child Hlth & Dis Tr, Dept Radyol, Ankara, Turkey
[4] Univ Hlth Sci, Dr Sami Ulus Gynecol Obstet & Child Hlth & Dis Tr, Dept Pediat Cardiol, Ankara, Turkey
关键词
Supraventricular tachycardia; necrotizing enterocolitis; mesenchymal stem cell; newborn; THERAPY;
D O I
10.1080/15513815.2019.1693672
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Background: Necrotizing enterocolitis (NEC) is one of the most important life- threatening diseases in neonates. Recurrent episodes of supraventricular tachycardia (SVT) can lead to gut ischemia, with subsequent reperfusion injury resulting in NEC. Mesenchymal stem cells (MSCs) are multi-potential cells which can differentiate into multiple cell types. Case report: A 22-day old male baby delivered to 34 yr old mother at 37-weeks' gestation via cesarean section, birth weight 3550 g, developed NEC 14 hours after being treated with cardioversion for SVT. At laparotomy, there was pan-NEC, and 60 cm of necrotic and perforated bowel was resected. 1 x 10(7) umbilical cord origin allogeneic MSCs were given intravenously, with subsequent improvement of the remaining bowel. Conclusion: MSC may be a promising treatment for adjacent ischemic bowel in NEC helping prevent short bowel syndrome.
引用
收藏
页码:250 / 255
页数:6
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