Successful Mesenchymal Stem Cell Application in Supraventricular Tachycardia-Related Necrotizing Enterocolitis: A Case Report

被引：26

作者：

Akduman, Hasan ^{[1
]}

Dilli, Dilek ^{[1
]}

Ergun, Ergun ^{[2
]}

Cakmakci, Emin ^{[3
]}

Celebi, Serpil Kaya ^{[4
]}

Citli, Rumeysa ^{[1
]}

Zenciroglu, Aysegul ^{[1
]}

机构：

[1] Univ Hlth Sci, Dr Sami Ulus Gynecol Obstet & Child Hlth & Dis Tr, Dept Neonatol, TR-06080 Ankara, Turkey

[2] Univ Hlth Sci, Dr Sami Ulus Gynecol Obstet & Child Hlth & Dis Tr, Dept Pediat Surg, Ankara, Turkey

[3] Univ Hlth Sci, Dr Sami Ulus Gynecol Obstet & Child Hlth & Dis Tr, Dept Radyol, Ankara, Turkey

[4] Univ Hlth Sci, Dr Sami Ulus Gynecol Obstet & Child Hlth & Dis Tr, Dept Pediat Cardiol, Ankara, Turkey

来源：

FETAL AND PEDIATRIC PATHOLOGY | 2021年 / 40卷 / 03期

关键词：

Supraventricular tachycardia; necrotizing enterocolitis; mesenchymal stem cell; newborn; THERAPY;

D O I：

10.1080/15513815.2019.1693672

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Background: Necrotizing enterocolitis (NEC) is one of the most important life- threatening diseases in neonates. Recurrent episodes of supraventricular tachycardia (SVT) can lead to gut ischemia, with subsequent reperfusion injury resulting in NEC. Mesenchymal stem cells (MSCs) are multi-potential cells which can differentiate into multiple cell types. Case report: A 22-day old male baby delivered to 34 yr old mother at 37-weeks' gestation via cesarean section, birth weight 3550 g, developed NEC 14 hours after being treated with cardioversion for SVT. At laparotomy, there was pan-NEC, and 60 cm of necrotic and perforated bowel was resected. 1 x 10(7) umbilical cord origin allogeneic MSCs were given intravenously, with subsequent improvement of the remaining bowel. Conclusion: MSC may be a promising treatment for adjacent ischemic bowel in NEC helping prevent short bowel syndrome.

引用

页码：250 / 255

页数：6

共 11 条

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