Pterostilbene fluorescent probes as potential tools for targeting neurodegeneration in biological applications

被引:1
|
作者
Ciccone, Lidia [1 ,2 ]
Nencetti, Susanna [1 ,2 ]
Marino, Maria [3 ]
Battocchio, Chiara [3 ]
Iucci, Giovanna [3 ]
Venditti, Iole [3 ]
Marsotto, Martina [3 ]
Montalesi, Emiliano [3 ]
Socci, Simone [4 ]
Bargagna, Beatrice [4 ]
Orlandini, Elisabetta [4 ,5 ]
机构
[1] Univ Pisa, Dept Pharm, Via Bonanno 6, I-56126 Pisa, Italy
[2] Univ Pisa, CISUP Ctr Instrumentat Sharing, Pisa, Italy
[3] Univ Roma Tre, Dept Sci, Rome, Italy
[4] Univ Pisa, Dept Earth Sci, Via Santa Maria 53, I-56126 Pisa, Italy
[5] Univ Pisa, Res Ctr E Piaggio, Pisa, Italy
关键词
Ptb fluorescent probes; spectrophotometric; pterostilbene 7-nitrobenzofurazan (NBD) derivative; pterostilbene rhodamine-B-isothiocyanate (Rhd B-Itc) derivative; citotoxicity; RESVERATROL; NEUROPROTECTION; NANOPARTICLES; TRIAL;
D O I
10.1080/14756366.2022.2091556
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Several epidemiological studies suggest that a diet rich in fruit and vegetables reduces the incidence of neurodegenerative diseases. Resveratrol (Res) and its dimethylated metabolite, pterostibene (Ptb), have been largely studied for their neuroprotective action. The clinical use of Res is limited because of its rapid metabolism and its poor bioavailability. Ptb with two methoxy groups and one hydroxyl group has a good membrane permeability, metabolic stability and higher in vivo bioavailability in comparison with Res. The metabolism and pharmacokinetics of Ptb are still sparse, probably due to the lack of tools that allow following the Ptb destiny both in living cells and in vivo. In this contest, we propose two Ptb fluorescent derivatives where Ptb has been functionalised by benzofurazan and rhodamine-B-isothiocyanate, compounds 1 and 2, respectively. Here, we report the synthesis, the optical and structural characterisation of 1 and 2, and, their putative cytotoxicity in two different cell lines.
引用
收藏
页码:1812 / 1820
页数:9
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