Cell Adhesion, the Backbone of the Synapse: "Vertebrate" and "Invertebrate" Perspectives

被引：76

作者：

Giagtzoglou, Nikolaos ^{[1
]}

Ly, Cindy V. ^{[2
]}

Bellen, Hugo J. ^{[1
,2
,3
,4
]}

机构：

[1] Baylor Coll Med, Howard Hughes Med Inst, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[4] Baylor Coll Med, Program Dev Biol, Houston, TX 77030 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2009年 / 1卷 / 04期

关键词：

DROSOPHILA VISUAL-SYSTEM; LONG-TERM POTENTIATION; IMMUNOGLOBULIN-LIKE PROTEIN; AUTISM SPECTRUM DISORDERS; SENSORY AXON GUIDANCE; RICH REPEAT PROTEINS; CHICK OPTIC TECTUM; N-CADHERIN; LIPRIN-ALPHA; NERVOUS-SYSTEM;

D O I：

10.1101/cshperspect.a003079

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Synapses are asymmetric intercellular junctions that mediate neuronal communication. The number, type, and connectivity patterns of synapses determine the formation, maintenance, and function of neural circuitries. The complexity and specificity of synaptogenesis relies upon modulation of adhesive properties, which regulate contact initiation, synapse formation, maturation, and functional plasticity. Disruption of adhesion may result in structural and functional imbalance that may lead to neurodevelopmental diseases, such as autism, or neurodegeneration, such as Alzheimer's disease. Therefore, understanding the roles of different adhesion protein families in synapse formation is crucial for unraveling the biology of neuronal circuit formation, as well as the pathogenesis of some brain disorders. The present review summarizes some of the knowledge that has been acquired in vertebrate and invertebrate genetic model organisms.

引用

页数：25

共 264 条

[1] Stability of dendritic spines and synaptic contacts is controlled by αN-catenin [J].

Abe, K ;

Chisaka, O ;

van Roy, F ;

Takeichi, M .

NATURE NEUROSCIENCE, 2004, 7 (04) :357-363

[2] Advances in autism genetics: on the threshold of a new neurobiology [J].

Abrahams, Brett S. ;

Geschwind, Daniel H. .

NATURE REVIEWS GENETICS, 2008, 9 (05) :341-355

[3] The two isoforms of the Caenorhabditis elegans leukocyte-common antigen related receptor tyrosine phosphatase PTP-3 function independently in axon guidance and synapse formation [J].

Ackley, BD ;

Harrington, RJ ;

Hudson, ML ;

Williams, L ;

Kenyon, CJ ;

Chisholm, AD ;

Jin, Y .

JOURNAL OF NEUROSCIENCE, 2005, 25 (33) :7517-7528

[4] Cadherins and catenins at synapses: roles in synaptogenesis and synaptic plasticity [J].

Arikkath, Jyothi ;

Reichardt, Louis F. .

TRENDS IN NEUROSCIENCES, 2008, 31 (09) :487-494

[5]

Artero RD, 2001, DEVELOPMENT, V128, P4251

[6] ADIP, a novel afadin- and α-actinin-binding protein localized at cell-cell adherens junctions [J].

Asada, M ;

Irie, K ;

Morimoto, K ;

Yamada, A ;

Ikeda, W ;

Takeuchi, M ;

Takai, Y .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (06) :4103-4111

[7] Deletion of CASK in mice is lethal and impairs synaptic function [J].

Atasoy, Deniz ;

Schoch, Susanne ;

Ho, Angela ;

Nadasy, Krisztina A. ;

Liu, Xinran ;

Zhang, Weiqi ;

Mukherjee, Konark ;

Nosyreva, Elena D. ;

Fernandez-Chacon, Rafael ;

Missler, Markus ;

Kavalali, Ege T. ;

Suedhof, Thomas C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (07) :2525-2530

[8]

Baines RA, 2002, J NEUROSCI, V22, P6587

[9] Preferential adhesion mediated by Hibris and roughest regulates morphogenesis and patterning in the Drosophila eye [J].

Bao, SJ ;

Cagan, R .

DEVELOPMENTAL CELL, 2005, 8 (06) :925-935

[10] Outline structure of the human L1 cell adhesion molecule and the sites where mutations cause neurological disorders [J].

Bateman, A ;

Jouet, M ;

MacFarlane, J ;

Du, JS ;

Kenwrick, S ;

Chothia, C .

EMBO JOURNAL, 1996, 15 (22) :6050-6059

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