Striatal circuits, habits, and implications for obsessive-compulsive disorder

被引：184

作者：

Burguiere, Eric ^{[1
]}

Monteiro, Patricia ^{[2
]}

Mallet, Luc ^{[1
]}

Feng, Guoping ^{[2
]}

Graybiel, Ann M. ^{[2
]}

机构：

[1] UPMC P6 UMR S 1127, Hop La Pitie Salpetriere, Brain & Spine Inst ICM, CNRS UMR 7225,Inserm U1127, F-75013 Paris, France

[2] MIT, McGovern Inst Brain Res, Cambridge, MA 02139 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2015年 / 30卷

关键词：

DEEP BRAIN-STIMULATION; ORBITOFRONTAL CORTEX; SUBTHALAMIC NUCLEUS; BASAL GANGLIA; BEHAVIORS; CHECKING; INTERNEURONS; METAANALYSIS; DYSFUNCTION; INDIVIDUALS;

D O I：

10.1016/j.conb.2014.08.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Increasing evidence implicates abnormalities in corticostriatal circuits in the pathophysiology of obsessive compulsive disorder (DOD) and OC-spectrum disorders. Parallels between the emergence of repetitive, compulsive behaviors and the acquisition of automated behaviors suggest that the expression of compulsions could in part involve loss of control of such habitual behaviors. The view that striatal circuit dysfunction is involved in OC-spectrum disorders is strengthened by imaging and other evidence in humans, by discovery of genes related to OCD syndromes, and by functional studies in animal models of these disorders. We highlight this growing concordance of work in genetics and neurobiology suggesting that frontostriatal circuits, and their links with basal ganglia, thalamus and brainstem, are promising candidates for therapeutic intervention in DOD.

引用

页码：59 / 65

页数：7

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