Tamoxifen inhibits astrocytic JAK2/STAT3 pathway in rats with traumatic spinal injury

Purpose: To investigate the reducing effect of Morinda citrifolia capsules (MCC) on total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in hypercholesterolemia patients. Methods: This study was a randomized double-blind placebo-controlled clinical trial, with 60 subjects placed in two groups, viz, experimental (MCC group) and placebo (P group). The first group received two capsules of MCC (each capsule contains 500 mg extract) while the second group received two capsules of placebo (comprised of 500 mg fillers) 3 times daily, for 14 days for both groups. Overnight fasting cubiti venous blood (3 mL) was taken from each subject each time measurements were carried out. TC and LDL-C were measured by spectrophotometric assay using an automated analyzer. Results: The results show that there was significant decrease in TC and LDL-C on day 14, compared to control (P group). Reduction in TC and LDL-C was 13.8 and 15.5 %, respectively. Decrease in TC and LDL-C levels was influenced by factors, such as age, BMI, exercise, diet, and smoking habits. In MCC group, the capsules significantly decreased TC levels (p < 0.05). Conclusion: The results suggest that 1 g MCC, given orally thrice daily, significantly reduces TC and LDL-C levels in patients with hypercholesterolemia.