Benzodiazepine modulation of GABAergic responses is intact in the cerebellum of aged F344 rats

被引：13
作者：
Bickford, PC
Breiderick, L
机构：
[1] Dept Vet Affairs Med Ctr, Res Serv 151, Denver, CO 80220 USA
[2] Univ Colorado, Hlth Sci Ctr, Dept Pharmacol, Denver, CO 80262 USA
[3] Univ Colorado, Hlth Sci Ctr, Neurosci Training Program, Denver, CO USA
来源：
NEUROSCIENCE LETTERS | 2000年 / 291卷 / 03期
关键词：
aging; benzodiazepine; modulation; F344; rat; cerebellum;
D O I：
10.1016/S0304-3940(00)01417-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
During the aging process there is a decline in the function of many central nervous system receptor systems. In this report we examine the ability of midazolam to potentiate gamma-aminobutyric acid (GABA) mediated inhibition recorded from cerebellar Purkinje neurons using extracellular recording methods. We report that when midazolam is applied concurrently with GABA from glass multibarrel electrodes that midazolam potentiates GABA mediated inhibition in 46% of Purkinje neurons in 3-month-old F344 rats, 63% of neurons in 18-month-old F344 rats and 54% of cells in 24-month-old F344 rats. Thus, there is no age related decline in function of this response. In fact, the response to midazolam is significantly increased in 18-month-old rats. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：187 / 190
页数：4
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