Intestinal Dysbiosis in the Infant and the Future of Lacto-Engineering to Shape the Developing Intestinal Microbiome

被引：3
作者：
Zeinali, Lida, I [1 ]
Giuliano, Shayne [2 ]
Lakshminrusimha, Satyan [1 ]
Underwood, Mark A. [1 ]
机构：
[1] Univ Calif Davis, Sch Med, Dept Pediat, Sacramento, CA 95817 USA
[2] 108Labs LLC, Davis, CA USA
来源：
CLINICAL THERAPEUTICS | 2022年 / 44卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Human milk oligosaccharides; Human milk immunoglobulins; Lactoferrin; Bile salt stimulated lipase; Lysozyme; Milk fat globule membrane; HUMAN-MILK OLIGOSACCHARIDES; SALT-STIMULATED LIPASE; RECOMBINANT HUMAN LACTOFERRIN; RANDOMIZED CONTROLLED-TRIAL; BIRTH-WEIGHT INFANTS; HUMAN GUT MICROBIOME; BREAST-FED INFANTS; ESCHERICHIA-COLI; INFLAMMATORY CYTOKINES; NECROTIZING ENTEROCOLITIS;
D O I：
10.1016/j.clinthera.2021.11.005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Purpose: The goal of this study was to review the role of human milk in shaping the infant intestinal microbiota and the potential of human milk bioactive molecules to reverse trends of increasing intestinal dysbiosis and dysbiosis-associated diseases. Methods: This narrative review was based on recent and historic literature. Findings: Human milk immunoglobulins, oligosaccharides, lactoferrin, lysozyme, milk fat globule membranes, and bile salt-stimulating lipase are complex multifunctional bioactive molecules that, among other important functions, shape the composition of the infant intestinal microbiota. (C) 2021 Elsevier Inc.
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页码：193 / +
页数：23
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