New syntheses of indole phytoalexins and related compounds

被引：54
作者：
Kutschy, P
Dzurilla, M
Takasugi, M
Török, M
Achbergerová, I
Homzová, R
Rácová, M
机构：
[1] Safarik Univ, Fac Nat Sci, Dept Organ Chem, SK-04167 Kosice, Slovakia
[2] Hokkaido Univ, Grad Sch Environm Earth Sci, Div Sci Mat, Sapporo, Hokkaido 060, Japan
来源：
TETRAHEDRON | 1998年 / 54卷 / 14期
关键词：
D O I：
10.1016/S0040-4020(98)00088-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Synthesis of indole phytoalexins brassinin, brassitin, cyclobrassinin and related compounds via 3-aminomethylindole and its 1-substituted derivatives obtained by nickel boride catalyzed reduction of corresponding aldoximes with sodium borohydride and via [1-(t-butoxycarbonyl)-indol-3-yl]methyl isothiocyanate, the first stable derivative of indol-3-ylmethyl isothiocyanate is described. Antifungal activity of the prepared compounds was examined by using the fungus Bipolaris leersiae by t.l.c. bioassay and quantitative screening was carried out with the selected compounds. (C) 1998 Elsevier Science Ltd. All rights reserved.
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收藏
页码：3549 / 3566
页数：18
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