Liquid biopsies in lung cancer: The new ambrosia of researchers

被引：141

作者：

Rolfo, Christian ^{[1
]}

Castiglia, Marta ^{[2
,3
]}

Hong, David ^{[4
]}

Alessandro, Riccardo ^{[5
]}

Mertens, Inge ^{[6
,7
]}

Baggerman, Geert ^{[6
,7
]}

Zwaenepoel, Karen ^{[2
]}

Gil-Bazo, Ignacio ^{[8
]}

Passiglia, Francesco ^{[1
,3
]}

Carreca, Anna P. ^{[1
,2
]}

Taverna, Simona ^{[5
]}

Vento, Renza ^{[9
]}

Peeters, Marc ^{[10
]}

Russo, Antonio ^{[3
]}

Pauwels, Patrick ^{[2
]}

机构：

[1] Univ Antwerp Hosp, Dept Oncol, Phase Early Clin Trials Unit 1, B-2650 Edegem, Belgium

[2] Univ Antwerp Hosp, Dept Pathol, Mol Pathol Unit, B-2650 Edegem, Belgium

[3] Univ Palermo, Sect Med Oncol, Dept Surg Oncol & Oral Sci, I-90127 Palermo, Italy

[4] Univ Texas MD Anderson Canc Ctr, Dept Invest Canc Therapeut, Phase Program 1, Houston, TX 77030 USA

[5] Univ Palermo, Sect Biol & Genet, Dept Biopathol & Med & Forens Biotechnol, I-90133 Palermo, Italy

[6] VITO, Ctr Prote, BE-2400 Mol, Belgium

[7] Univ Antwerp, B-2020 Antwerp, Belgium

[8] Univ Navarra Clin, Dept Oncol, Lung Canc Unit, Pamplona 31008, Spain

[9] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol, Biochem Lab, I-90128 Palermo, Italy

[10] Univ Antwerp Hosp, Dept Oncol, B-2650 Edegem, Belgium

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2014年 / 1846卷 / 02期

关键词：

Circulating tumor cells; Exosomes; Circulating tumor DNA; Lung cancer; Biomarkers; CIRCULATING TUMOR-CELLS; FREE DNA; BIOMARKER DISCOVERY; PANCREATIC-CANCER; DIAGNOSTIC MARKER; PROTEOME ANALYSIS; PERIPHERAL-BLOOD; PROGNOSTIC VALUE; PROGRESSION-FREE; EGFR MUTATIONS;

D O I：

10.1016/j.bbcan.2014.10.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the last decades the approach to cancer patient management has been deeply revolutionized. We are moving from a "one-fits-all" strategy to the "personalized medicine" based on the molecular characterization of the tumor. In this new era it is becoming more and more clear that the monitoring of the disease is fundamental for the success of the treatment, thus there is the need of new biomarker discovery. More precisely in the last years the scientific community has started to use the term "liquid biopsy". A liquid biopsy is a liquid biomarker that can be easily isolated from many body fluids (blood, saliva, urine, ascites, pleural effusion, etc.) and, as well as a tissue biopsy, a representative of the tissue from which it is spread. In this review we will focus our attention on circulating tumor cells, circulating tumor DNA, exosomes and secretomes with the aim to underlie their usefulness and potential application in a clinical setting for lung cancer patient management. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：539 / 546

页数：8

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