Respiratory transmission of an avian H3N8 influenza virus isolated from a harbour seal

被引：55

作者：

Karlsson, Erik A. ^{[1
]}

Ip, Hon S. ^{[2
]}

Hall, Jeffrey S. ^{[2
]}

Yoon, Sun Woo ^{[1
]}

Johnson, Jordan ^{[1
]}

Beck, Melinda A. ^{[3
]}

Webby, Richard J. ^{[1
]}

Schultz-Cherry, Stacey ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA

[2] US Geol Survey, Natl Wildlife Hlth Ctr, Madison, WI 53711 USA

[3] Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA

来源：

NATURE COMMUNICATIONS | 2014年 / 5卷

基金：

美国国家卫生研究院;

关键词：

HEMAGGLUTININ; FERRETS; EQUINE; REPLICATION; ADAPTATION; SEQUENCE; BINDING; MICE;

D O I：

10.1038/ncomms5791

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The ongoing human H7N9 influenza infections highlight the threat of emerging avian influenza viruses. In 2011, an avian H3N8 influenza virus isolated from moribund New England harbour seals was shown to have naturally acquired mutations known to increase the transmissibility of highly pathogenic H5N1 influenza viruses. To elucidate the potential human health threat, here we evaluate a panel of avian H3N8 viruses and find that the harbour seal virus displays increased affinity for mammalian receptors, transmits via respiratory droplets in ferrets and replicates in human lung cells. Analysis of a panel of human sera for H3N8 neutralizing antibodies suggests that there is no population-wide immunity to these viruses. The prevalence of H3N8 viruses in birds and multiple mammalian species including recent isolations from pigs and evidence that it was a past human pandemic virus make the need for surveillance and risk analysis of these viruses of public health importance.

引用

页数：7

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