Genetics of Primary Arterial Hypertension

被引：0

作者：

Algharably, Engi ^{[1
]}

Bolbrinker, Juliane ^{[1
]}

Kreutz, Reinhold ^{[1
]}

机构：

[1] Charite Univ Med Berlin, Inst Klin Pharmakol & Toxikol, Charitepl 1, D-10117 Berlin, Germany

来源：

AKTUELLE KARDIOLOGIE | 2019年 / 8卷 / 05期

关键词：

genetics; hypertension; pharmacogenetics; BLOOD-PRESSURE; ASSOCIATION; VARIANTS;

D O I：

10.1055/a-0993-5354

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The dissection of the molecular genetic basis of primary hypertension is subject of intensive research and has recently made rapid progress. Genome-wide association studies (GWAS) and theirmeta-analyses play an important role. Based on recent studies, more than 900 independent blood pressure associated loci across the genome have been identified. In addition to a better understanding of the mechanisms involved in the pathogenesis of hypertension, a risk assessment for the development of hypertension can be envisioned in the future. Furthermore, the results may enable the development of new drugs and individualized therapy strategies (pharmacogenetics) for hypertension. However, these results are not yet relevant for the management of primary hypertension in clinical practice.

引用

页码：349 / 353

页数：5

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