The Functions of MicroRNA-200 Family in Ovarian Cancer: Beyond Epithelial-Mesenchymal Transition

被引：65
作者：
Choi, Pui-Wah [1 ]
Ng, Shu-Wing [1 ]
机构：
[1] Harvard Med Sch, Brigham & Womens Hosp, Dept Obstet Gynecol & Reprod Biol, Div Gynecol Oncol, Boston, MA 02115 USA
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 06期
关键词：
ovarian cancer; microRNA-200; epithelial-mesenchymal transition; COLLECTIVE CELL-MOVEMENT; E-CADHERIN EXPRESSION; III BETA-TUBULIN; MIR-200; FAMILY; SURFACE EPITHELIUM; LUNG-CANCER; INCESSANT OVULATION; CANDIDATE PRECURSOR; SEROUS CARCINOMA; FALLOPIAN-TUBE;
D O I：
10.3390/ijms18061207
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The majority of studies on microRNA-200 family members (miR-200s) in human cancers are based on the premise that miR-200s maintain epithelial cell integrity by suppressing epithelial-mesenchymal transition (EMT) through direct inhibition of mesenchymal transcription factors zinc finger E-box-binding homeobox 1/2 (ZEB1/ZEB2) and transforming growth factor-beta (TGF-beta), a potent inducer of EMT. Hence, downregulation of miR-200 in cancer cells promotes EMT and cancer metastasis. Yet, miR-200s are highly expressed in ovarian cancer, and ovarian cancer metastasizes primarily by dissemination within the pelvic cavity. In this review, we will refocus the epithelial property of ovarian cancer cells and the role of miR-200s in safeguarding this property, as well as the diverse roles of miR-200s in inclusion cyst formation, cancer cell growth, collective movement, angiogenesis, exosome-mediated cell communication, and chemoresponse. Taken together, miR-200s play a significant role in the initiation, progression and metastasis of ovarian cancer and may serve as diagnostic biomarkers and a target in therapeutic development.
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页数：20
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共 130 条
[1]   Novel action of paclitaxel against cancer cells: Bystander effect mediated by reactive oxygen species [J].
Alexandre, Jerome ;
Hu, Yumin ;
Lu, Weiqin ;
Pelicano, Helene ;
Huang, Peng .
CANCER RESEARCH, 2007, 67 (08) :3512-3517
[2]   E-cadherin expression in ovarian cancer in the laying hen, Gallus domesticus, compared to human ovarian cancer [J].
Ansenberger, Kristine ;
Zhuge, Yan ;
Lagman, Jo Ann J. ;
Richards, Cassandra ;
Barua, Animesh ;
Bahr, Janice M. ;
Hales, Dale Buchanan .
GYNECOLOGIC ONCOLOGY, 2009, 113 (03) :362-369
[3]  
Auersperg N, 1997, J CELL PHYSIOL, V173, P261, DOI 10.1002/(SICI)1097-4652(199711)173:2<261::AID-JCP32>3.0.CO
[4]  
2-G
[5]   A pilot study of ovarian cancer chemoprevention using medroxyprogesterone acetate in an avian model of spontaneous ovarian carcinogenesis [J].
Barnes, MN ;
Berry, WD ;
Straughn, JMJ ;
Kirby, TO ;
Leath, CA ;
Huh, WK ;
Grizzle, WE ;
Partridge, EE .
GYNECOLOGIC ONCOLOGY, 2002, 87 (01) :57-63
[6]   miR-200 family controls late steps of postnatal forebrain neurogenesis via Zeb2 inhibition [J].
Beclin, Christophe ;
Follert, Philipp ;
Stappers, Elke ;
Barral, Serena ;
Nathalie, Core ;
de Chevigny, Antoine ;
Magnone, Virginie ;
Lebrigand, Kevin ;
Bissels, Ute ;
Huylebroeck, Danny ;
Bosio, Andreas ;
Barbry, Pascal ;
Seuntjens, Eve ;
Cremer, Harold .
SCIENTIFIC REPORTS, 2016, 6
[7]   Regulation of vimentin by SIP1 in human epithelial breast tumor cells [J].
Bindels, S. ;
Mestdagt, M. ;
Vandewalle, C. ;
Jacobs, N. ;
Volders, L. ;
Noel, A. ;
van Roy, F. ;
Berx, G. ;
Foidart, J-M ;
Gilles, C. .
ONCOGENE, 2006, 25 (36) :4975-4985
[8]   A tale of two proteins:: Differential roles and regulation of Smad2 and Smad3 in TGF-β signaling [J].
Brown, Kimberly A. ;
Pietenpol, Jennifer A. ;
Moses, Harold L. .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2007, 101 (01) :9-33
[9]   The miR-200 family differentially regulates sensitivity to paclitaxel and carboplatin in human ovarian carcinoma OVCAR-3 and MES-OV cells [J].
Brozovic, Anamaria ;
Duran, George E. ;
Wang, Yan C. ;
Francisco, E. Brian ;
Sikic, Branimir I. .
MOLECULAR ONCOLOGY, 2015, 9 (08) :1678-1693
[10]   A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells [J].
Burk, Ulrike ;
Schubert, Joerg ;
Wellner, Ulrich ;
Schmalhofer, Otto ;
Vincan, Elizabeth ;
Spaderna, Simone ;
Brabletz, Thomas .
EMBO REPORTS, 2008, 9 (06) :582-589
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