Metabolic circuits in neural stem cells

被引：45
作者：
Kim, Do-Yeon [1 ]
Rhee, Inmoo [1 ,2 ]
Paik, Jihye [1 ]
机构：
[1] Weill Cornell Med Coll, Dept Pathol & Lab Med, New York, NY 10065 USA
[2] Gachon Univ, Sch Med, Dept Biochem, Incheon 406799, South Korea
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2014年 / 71卷 / 21期
关键词：
Neural stem/progenitor cells; Metabolism; Self-renewal; Differentiation; ADULT SUBVENTRICULAR ZONE; TUMOR-SUPPRESSOR P53; GROWTH-FACTOR-I; GLUTAMINE-METABOLISM; SELF-RENEWAL; C-MYC; HIPPOCAMPAL NEUROGENESIS; AEROBIC GLYCOLYSIS; ENERGY-METABOLISM; OXIDATIVE STRESS;
D O I：
10.1007/s00018-014-1686-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Metabolic activity indicative of cellular demand is emerging as a key player in cell fate decision. Numerous studies have demonstrated that diverse metabolic pathways have a critical role in the control of the proliferation, differentiation and quiescence of stem cells. The identification of neural stem/progenitor cells (NSPCs) and the characterization of their development and fate decision process have provided insight into the regenerative potential of the adult brain. As a result, the potential of NSPCs in cell replacement therapies for neurological diseases is rapidly growing. The aim of this review is to discuss the recent findings on the crosstalk among key regulators of NSPC development and the metabolic regulation crucial for the function and cell fate decisions of NSPCs. Fundamental understanding of the metabolic circuits in NSPCs may help to provide novel approaches for reactivating neurogenesis to treat degenerative brain conditions and cognitive decline.
引用
收藏
页码：4221 / 4241
页数：21
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