Perfluorinated alkyl acids in the serum and follicular fluid of UK women with and without polycystic ovarian syndrome undergoing fertility treatment and associations with hormonal and metabolic parameters

被引：76

作者：

Heffernan, A. L. ^{[1
,2
]}

Cunningham, T. K. ^{[3
,4
]}

Drage, D. S. ^{[1
,5
]}

Aylward, L. L. ^{[1
,6
]}

Thompson, K. ^{[1
]}

Vijayasarathy, S. ^{[1
]}

Mueller, J. F. ^{[1
]}

Atkin, S. L. ^{[7
]}

Sathyapalan, T. ^{[3
]}

机构：

[1] Univ Queensland, Queensland Alliance Environm Hlth Sci, Brisbane, Qld, Australia

[2] Univ Melbourne, Melbourne Dementia Res Ctr, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia

[3] Univ Hull, Ctr Cardiovasc & Metab Res, Hull York Med Sch, Kingston Upon Hull, N Humberside, England

[4] Hull Royal Infirm, Hull IVF Unit, Womens & Childrens Hosp, Kingston Upon Hull, N Humberside, England

[5] Univ Birmingham, Sch Geog Earth & Environm Sci, Birmingham, W Midlands, England

[6] Summit Toxicol LLP, Lyons, CO USA

[7] Qatar Fdn, Weill Cornell Med Qatar, Doha, Qatar

来源：

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH | 2018年 / 221卷 / 07期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

Polycystic ovary syndrome; PCOS; IVF; PFAA; Endocrine disrupting chemicals; Perfluorinated alkyl acids; PFOS; PFOA; PFHxS; PFNA; ENDOCRINE DISRUPTING CHEMICALS; GLOMERULAR-FILTRATION-RATE; PERFLUOROALKYL ACIDS; THYROID-FUNCTION; POLYFLUOROALKYL SUBSTANCES; PRENATAL EXPOSURE; PERFLUOROOCTANE SULFONATE; NATIONAL-HEALTH; KIDNEY-FUNCTION; TESTOSTERONE;

D O I：

10.1016/j.ijheh.2018.07.009

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Women with polycystic ovarian syndrome (PCOS) undergoing treatment for infertility could be a sensitive subpopulation for endocrine effects of exposure to perfluorinated alkyl acids (PFAAs), persistent organic pollutants with potential endocrine activity. Women with, PCOS (n = 30) and age- and BMI-matched controls (n = 29) were recruited from a UK fertility clinic in 2015. Paired serum and follicular fluid samples were collected and analysed for 13 PFAAs. Sex steroid and thyroid hormones, and metabolic markers were measured and assessed for associations with serum PFAAs. Four PFAAs were detected in all serum and follicular fluid samples and concentrations in the two matrices were highly correlated (R-2 > 0.95): perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonate (PFHxS), and perfluorononanoic acid (PFNA). Serum PFOS was positively associated with age (1 ng/mL per yr, p < 0.05) and was higher in PCOS cases than controls (geometric mean [GM] 3.9 vs. 3.1 ng/mL, p < 0.05) and in women with irregular vs. regular menstrual cycles (GM 3.9 vs. 3.0 ng/mL, p = 0.01). After adjustment for confounders, serum testosterone was significantly associated with PFOA, PFHxS, PFNA, and the molar sum of the four frequently detected serum PFAAs (approximately 50 percent increase per In-unit) among controls but not PCOS cases. HbA1c in PCOS cases was inversely associated with serum PFOA, PFHxs, and sum of PFAAs (2-3 mmol/mol per 1n-unit). In controls, fasting glucose was positively associated with serum PFOA and sum of PFAAs (0.25 nmol/L per In-unit increase in PFAAs). Few other associations were observed. The analyses and findings here should be considered exploratory in light of the relatively small sample sizes and large number of statistical comparisons conducted. However, the data do not suggest increased sensitivity to potential endocrine effects of PFAAs in PCOS patients.

引用

页码：1068 / 1075

页数：8

共 67 条

[61] Associations of Perfluoroalkyl Substances (PFAS) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK) [J].