Vaccination for malaria based on genomics and proteomics

被引：1

作者：

Wiwanitkit, Viroj ^{[1
]}

机构：

[1] Chulalongkorn Univ, Fac Med, Dept Lab Med, Bangkok 10330, Thailand

来源：

DRUGS OF THE FUTURE | 2007年 / 32卷 / 02期

关键词：

D O I：

10.1358/dof.2007.032.02.1068848

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The field of vaccinology has benefited from new bioinformatics technologies. The complete genome sequences of malaria parasites have been deciphered and vaccines can now be targeted towards specific gene products that traditional vaccine research failed to discover. Advanced technologies for vaccine development, such as genome sequence analysis, microarrays, proteomics approaches, high-throughput cloning and bioinformatics database tools, and computational vaccinology, can be applied to the development of vaccines for several diseases, including malaria. New advances in malaria genomics, proteomics and immunomics should also contribute to successful malaria vaccine development.

引用

页码：171 / 177

页数：7

共 50 条

[1] High-throughput generation of P. falciparum functional molecules by recombinational cloning [J].

Aguiar, JC ;

LaBaer, J ;

Blair, PL ;

Shamailova, VY ;

Koundinya, M ;

Russell, JA ;

Huang, FY ;

Mar, W ;

Anthony, RM ;

Witney, A ;

Caruana, SR ;

Brizuela, L ;

Sacci, JB ;

Hoffman, SL ;

Carucci, DJ .

GENOME RESEARCH, 2004, 14 (10B) :2076-2082

[2] Vaccines: An ongoing promise? [J].

Alsahli, M ;

Farrell, RJ ;

Michetti, P .

DIGESTIVE DISEASES, 2001, 19 (02) :148-157

[3] Biotechnology and drug discovery: From bench to bedside [J].

Avidor, Y ;

Mabjeesh, NJ ;

Matzkin, H .

SOUTHERN MEDICAL JOURNAL, 2003, 96 (12) :1174-1186

[4] PlasmoDB:: the Plasmodium genome resource.: An integrated database providing tools for accessing, analyzing and mapping expression and sequence data (both finished and unfinished) [J].

Bahl, A ;

Brunk, B ;

Coppel, RL ;

Crabtree, J ;

Diskin, SJ ;

Fraunholz, MJ ;

Grant, GR ;

Gupta, D ;

Huestis, RL ;

Kissinger, JC ;

Labo, P ;

Li, L ;

McWeeney, SK ;

Milgram, AJ ;

Roos, DS ;

Schug, J ;

Stoeckert Jr, CJ .

NUCLEIC ACIDS RESEARCH, 2002, 30 (01) :87-90

[5] Expression library immunization to discover and improve vaccine antigens [J].

Barry, MA ;

Howell, DPG ;

Andersson, HA ;

Chen, JL ;

Singh, RAK .

IMMUNOLOGICAL REVIEWS, 2004, 199 (01) :68-83

[6] High throughput cloning and expression strategies for protein production [J].

Betton, JM .

BIOCHIMIE, 2004, 86 (9-10) :601-605

[7] JenPep: a database of quantitative functional peptide data for immunology [J].

Blythe, MJ ;

Doytchinova, IA ;

Flower, DR .

BIOINFORMATICS, 2002, 18 (03) :434-439

[8] Information technologies for vaccine research [J].

Brusic, Vladimir ;

August, J. Thomas ;

Petrovsky, Nikolai .

EXPERT REVIEW OF VACCINES, 2005, 4 (03) :407-417

[9]

Brusic Vladimir, 2003, J Bioinform Comput Biol, V1, P179, DOI 10.1142/S0219720003000034

[10]

Capecchi B, 2004, CURR ISSUES MOL BIOL, V6, P17

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