Gene-Environment Interactions and the Etiology of Birth Defects

被引：55

作者：

Krauss, Robert S. ^{[1
]}

Hong, Mingi ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Dev & Regenerat Biol, New York, NY 10029 USA

来源：

ESSAYS ON DEVELOPMENTAL BIOLOGY, PT A | 2016年 / 116卷

关键词：

CONGENITAL HEART-DISEASE; CLEFT-LIP; SHH; MUTATIONS; SPECTRUM; RECEPTOR; GAS1; CDO; EMBRYOGENESIS; PHENOTYPE;

D O I：

10.1016/bs.ctdb.2015.12.010

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

It is thought that most structural birth defects are caused by a complex combination of genetic and environmental factors that interact to interfere with morphogenetic processes. It is important not only to identify individual genetic and environmental risk factors for particular defects but also to identify which environmental factors interact specifically with which genetic variants that predispose to the same defect. Genomic and epidemiological studies are critical to this end. Development and analysis of model systems will also be essential for this goal, as well as for understanding the mechanisms that underlie specific gene-environment interactions.

引用

页码：569 / 580

页数：12

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