TRANSIENT RECEPTOR POTENTIAL VANILLOID 1 CHANNELS CONTROL ACETYLCHOLINE/2-ARACHIDONOYLGLICEROL COUPLING IN THE STRIATUM

被引：34

作者：

Musella, A. ^{[1
,2
]}

De Chiara, V. ^{[1
,2
]}

Rossi, S. ^{[1
,2
]}

Cavasinni, F. ^{[1
,2
]}

Castelli, M. ^{[1
,2
]}

Cantarella, C. ^{[1
,2
]}

Mataluni, G. ^{[1
,2
]}

Bernardi, G. ^{[1
,2
]}

Centonze, D. ^{[1
,2
]}

机构：

[1] Univ Roma Tor Vergata, Neurol Clin, Dipartimento Neurosci, I-00133 Rome, Italy

[2] Fdn Santa Lucia, CERC, Rome, Italy

来源：

NEUROSCIENCE | 2010年 / 167卷 / 03期

关键词：

anandamide; CB1; receptors; endocannabinoids; IPSC; muscarinic receptors; vanilloid receptors; LONG-TERM DEPRESSION; GLUTAMATERGIC SYNAPTIC-TRANSMISSION; SPINY PROJECTION NEURONS; CENTRAL-NERVOUS-SYSTEM; CHOLINERGIC INTERNEURONS; RAT STRIATUM; IN-VITRO; CANNABINOID RECEPTORS; ENDOCANNABINOID BIOSYNTHESIS; MUSCARINIC RECEPTORS;

D O I：

10.1016/j.neuroscience.2010.02.058

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neurotransmitter acetylcholine (Ach) controls both excitatory and inhibitory synaptic transmission in the striatum. Here, we investigated the involvement of the endocannabinoid system in Ach-mediated inhibition of striatal GABA transmission, and the potential role of transient receptor potential vanilloid 1 (TRPV1) channels in the control of Ach-endocannabinoid coupling. We found that inhibition of Ach degradation and direct pharmacological stimulation of muscarinic M1 receptors reduced striatal inhibitory postsynaptic currents (IPSCs) through the stimulation of 2-arachidonoylglicerol (2AG) synthesis and the activation of cannabinoid CB1 receptors. The effects of M1 receptor activation on IPSCs were occlusive with those of metabotropic glutamate receptor 5 stimulation, and were prevented in the presence of capsaicin, agonist of TRPV1 channels. Elevation of anandamide (AEA) tone with URB597, a blocker of fatty acid amide hydrolase, mimicked the effects of capsaicin, indicating that endogenous AEA acts as an endovanilloid substance in the control of M1-dependent 2AG-mediated synaptic effects in the striatum. Accordingly, both capsaicin and URB597 effects were absent in mice lacking TRPV1 channels. Pharmacological interventions targeting AEA metabolism and TRPV1 channels might be considered alternative therapeutic routes in disorders of striatal cholinergic or endocannabinoid neurotransmission. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：864 / 871

页数：8

共 62 条

[1] Cholinergic Interneurons Are Differentially Distributed in the Human Striatum [J].

Bernacer, Javier ;

Prensa, Lucia ;

Manuel Gimenez-Amaya, Jose .

PLOS ONE, 2007, 2 (11)

[2] Development of the first potent and specific inhibitors of endocannabinoid biosynthesis [J].

Bisogno, T ;

Cascio, MG ;

Saha, B ;

Mahadevan, A ;

Urbani, P ;

Minassi, A ;

Appendino, G ;

Saturnino, C ;

Martin, B ;

Razdan, R ;

Di Marzo, V .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2006, 1761 (02) :205-212

[3] Loss of muscarinic autoreceptor function impairs long-term depression but not long-term potentiation in the striatum [J].

Bonsi, Paola ;

Martella, Giuseppina ;

Cuomo, Dario ;

Platania, Paola ;

Sciamanna, Giuseppe ;

Bernardi, Giorgio ;

Wess, Juergen ;

Pisani, Antonio .

JOURNAL OF NEUROSCIENCE, 2008, 28 (24) :6258-6263

[4] Endogenous ACh enhances striatal NMDA-responses via M1-like muscarinic receptors and PKC activation [J].

Calabresi, P ;

Centonze, D ;

Gubellini, P ;

Pisani, A ;

Bernardi, G .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1998, 10 (09) :2887-2895

[5] Acetylcholine-mediated modulation of striatal function [J].

Calabresi, P ;

Centonze, D ;

Gubellini, P ;

Pisani, A ;

Bernardi, G .

TRENDS IN NEUROSCIENCES, 2000, 23 (03) :120-126

[6] The capsaicin receptor: a heat-activated ion channel in the pain pathway [J].

Caterina, MJ ;

Schumacher, MA ;

Tominaga, M ;

Rosen, TA ;

Levine, JD ;

Julius, D .

NATURE, 1997, 389 (6653) :816-824

[7] Abnormal sensitivity to cannabinoid receptor stimulation might contribute to altered gamma-aminobutyric acid transmission in the striaturn of R6/2 Huntington's disease mice [J].

Centonze, D ;

Rossi, S ;

Prosperetti, C ;

Tscherter, A ;

Bernardi, G ;

Maccarrone, M ;

Calabresi, P .

BIOLOGICAL PSYCHIATRY, 2005, 57 (12) :1583-1589

[8] The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis [J].

Centonze, Diego ;

Bari, Monica ;

Rossi, Silvia ;

Prosperetti, Chiara ;

Furlan, Roberto ;

Fezza, Filomena ;

De Chiara, Valentina ;

Battistini, Luca ;

Bernardi, Giorgio ;

Bernardini, Sergio ;

Martino, Gianvito ;

Maccarrone, Mauro .

BRAIN, 2007, 130 :2543-2553

[9] Endocannabinoids limit metabotropic glutamate 5 receptor-mediated synaptic inhibition of striatal principal neurons [J].

Centonze, Diego ;

Rossi, Silvia ;

Prosperetti, Chiara ;

Gasperi, Valeria ;

De Chiara, Valentina ;

Bari, Monica ;

Tscherter, Anne ;

Febbraro, Fabia ;

Bernardi, Giorgio ;

Maccarrone, Mauro .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2007, 35 (02) :302-310

[10] Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain [J].

Cristino, L. ;

De Petrocellis, L. ;

Pryce, G. ;

Baker, D. ;

Guglielmotti, V. ;

Di Marzo, V. .

NEUROSCIENCE, 2006, 139 (04) :1405-1415

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