Breast cancer: The upgraded role of HER-3 and HER-4

被引：53
作者：
Karamouzis, Michalis V.
Badra, Filitsa A.
Papavassiliou, Athanasios G.
机构：
[1] Univ Athens, Sch Med, Dept Biol Chem, GR-11527 Athens, Greece
[2] Thriass Gen Hosp, Dept Radiol, Athens, Greece
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2007年 / 39卷 / 05期
关键词：
breast cancer; ErbB receptors; HER-3; HER-4;
D O I：
10.1016/j.biocel.2006.11.017
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Breast cancer is the most common cancer in women and the ErbB receptor family holds crucial role in its pathogenesis. Among them, epidermal growth factor receptor and HER-2 are the most studied members and their overexpression has been associated with aggressive clinical behaviour. These data were further strengthened by the clinical success of trastuzumab, a monoclonal antibody against HER-2 in breast cancer patients with HER-2 overexpression and/or amplification. However, trastuzumab failure in some patients may partly be attributed to co-expression of other ErbB receptors. Herein, we provide updated views regarding the role of HER-3 and HER-4 in breast cancer. Accumulated evidence implies that these receptors should be considered more than heterodimerisation partners. Their expression profile might be useful in predicting responsiveness to current treatment options, while new strategies targeting their ligands and downstream effectors are being developed. (C) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：851 / 856
页数：6
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