Synthesis of substituted oxazoles from enamides

被引：18
作者：
Panda, Niranjan [1 ]
Mothkuri, Raghavender [1 ]
机构：
[1] Natl Inst Technol, Dept Chem, Rourkela 769008, Odisha, India
来源：
NEW JOURNAL OF CHEMISTRY | 2014年 / 38卷 / 12期
关键词：
OXIDATIVE CYCLIZATION; 2,5-DISUBSTITUTED OXAZOLES; BIOLOGICAL EVALUATION; EFFICIENT SYNTHESIS; C-N; ACID; INHIBITORS; DERIVATIVES; CHEMISTRY; THIAZOLE;
D O I：
10.1039/c4nj01101e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Annulation of enamides into 2,5- and 2,4,5-substituted oxazoles by NBS/Me2S in the presence of mild base has been achieved. The reaction conditions are simple and tolerant to a wide variety of substituents including both electron-donating and withdrawing groups to produce oxazotes in one-pot without further purification of the intermediate.
引用
收藏
页码：5727 / 5735
页数：9
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