NOD-like receptor (NLR) signaling beyond the inflammasome

被引：95
作者：
Shaw, Patrick J. [1 ]
Lamkanfi, Mohamed [2 ,3 ]
Kanneganti, Thirumala-Devi [1 ]
机构：
[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
[2] Univ Ghent, Dept Biochem, B-9000 Ghent, Belgium
[3] VIB, Dept Med Prot Res, Ghent, Belgium
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2010年 / 40卷 / 03期
关键词：
Inflammasome; Innate immunity; NLR; NF-KAPPA-B; CUTTING EDGE; INNATE; EXPRESSION; MONARCH-1; PROTEIN; SUSCEPTIBILITY; PEPTIDOGLYCAN; ACTIVATION; MUTATIONS;
D O I：
10.1002/eji.200940211
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recent years have witnessed a marked progress in our knowledge of NOD-like receptors (NLR), intracellular sensors with central roles in innate and adaptive immunity. A majority of the research has focused on caspase-1 inflammasomes. However, several members of the mammalian NLR family exert important roles in immunity beyond inflammasome signaling. Here we highlight the emerging roles of several of these NLR.
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收藏
页码：624 / 627
页数：4
相关论文
共 32 条
[1]   An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix [J].
Arnoult, Damien ;
Soares, Fraser ;
Tattoli, Ivan ;
Castanier, Celine ;
Philpott, Dana J. ;
Girardin, Stephen E. .
JOURNAL OF CELL SCIENCE, 2009, 122 (17) :3161-3168
[2]   Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases [J].
Chamaillard, M ;
Philpott, D ;
Girardin, SE ;
Zouali, H ;
Lesage, S ;
Chareyre, F ;
Bui, TH ;
Giovannini, M ;
Zaehringer, U ;
Penard-Lacronique, V ;
Sansonetti, PJ ;
Hugot, JP ;
Thomas, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (06) :3455-3460
[3]   Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression [J].
Chang, CH ;
Guerder, S ;
Hong, SC ;
vanEwijk, W ;
Flavell, RA .
IMMUNITY, 1996, 4 (02) :167-178
[4]   Involvement of receptor-interacting protein 2 in innate and adaptive immune responses [J].
Chin, AI ;
Dempsey, PW ;
Bruhn, K ;
Miller, JF ;
Xu, Y ;
Cheng, GH .
NATURE, 2002, 416 (6877) :190-194
[5]   Unleashing the therapeutic potential of NOD-like receptors [J].
Geddes, Kaoru ;
Magalhaes, Joao G. ;
Girardin, Stephen E. .
NATURE REVIEWS DRUG DISCOVERY, 2009, 8 (06) :465-479
[6]   Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection [J].
Girardin, SE ;
Boneca, IG ;
Viala, J ;
Chamaillard, M ;
Labigne, A ;
Thomas, G ;
Philpott, DJ ;
Sansonetti, PJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (11) :8869-8872
[7]   The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens [J].
Hsu, Yen-Michael S. ;
Zhang, Yongliang ;
You, Yun ;
Wang, Donghai ;
Li, Hongxiu ;
Duramad, Omar ;
Qin, Xiao-Feng ;
Dong, Chen ;
Lin, Xin .
NATURE IMMUNOLOGY, 2007, 8 (02) :198-205
[8]   Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease [J].
Hugot, JP ;
Chamaillard, M ;
Zouali, H ;
Lesage, S ;
Cézard, JP ;
Belaiche, J ;
Almer, S ;
Tysk, C ;
O'Morain, CA ;
Gassull, M ;
Binder, V ;
Finkel, Y ;
Cortot, A ;
Modigliani, R ;
Laurent-Puig, P ;
Gower-Rousseau, C ;
Macry, J ;
Colombel, JF ;
Sahbatou, M ;
Thomas, G .
NATURE, 2001, 411 (6837) :599-603
[9]   Mapping of a susceptibility locus for Crohn's disease on chromosome 16 [J].
Hugot, JP ;
LaurentPuig, P ;
GowerRousseau, C ;
Olson, JM ;
Lee, JC ;
Beaugerie, L ;
Naom, I ;
Dupas, JL ;
VanGossum, A ;
Orholm, M ;
BonaitiPellie, C ;
Weissenbach, J ;
Mathew, CG ;
LennardJones, JE ;
Cortot, A ;
Colombel, JF ;
Thomas, G .
NATURE, 1996, 379 (6568) :821-823
[10]   Mutations in NALP12 cause hereditary periodic fever syndromes [J].
Jeru, I. ;
Duquesnoy, P. ;
Fernandes-Alnemri, T. ;
Cochet, E. ;
Yu, J. W. ;
Lackmy-Port-Lis, M. ;
Grimprel, E. ;
Landman-Parker, J. ;
Hentgen, V. ;
Marlin, S. ;
McElreavey, K. ;
Sarkisian, T. ;
Grateau, G. ;
Alnemri, E. S. ;
Amselem, S. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (05) :1614-1619
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