Cell-Penetrating Peptide Technology to Deliver Chaperones and Associated Factors in Diseases and Basic Research

被引：70
作者：
Dietz, Gunnar P. H. [1 ]
机构：
[1] H Lundbeck & Co AS, Dep 828, Mol Neurobiol, DK-2500 Valby, Denmark
来源：
CURRENT PHARMACEUTICAL BIOTECHNOLOGY | 2010年 / 11卷 / 02期
关键词：
Protein delivery; Trojan horse; HIV-Tat; Antennapedia (Penetratin); arginine-rich peptide; Ischemia; stroke; Pep-1; SHOCK-RELATED PROTEIN; SMALL INTERFERING RNA; INTRACELLULAR DELIVERY; MEDIATED DELIVERY; MAMMALIAN-CELLS; EFFICIENTLY PROTECTS; ALPHA-SYNUCLEIN; STRESS-PROTEINS; BINDING DOMAIN; SIRNA DELIVERY;
D O I：
10.2174/138920110790909731
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cell-penetrating peptides (CPP), also called protein transduction domains (PTD), membrane-permeable peptides (MPP), or Trojan horse peptides, have been used in many different research areas. The delivery of heat shock proteins (Hsp) using CPP has been applied in models for apoptosis, necrosis, oxidative stress, neurodegenerative diseases, stroke, cystic fibrosis, smooth muscle relaxation, myocardial injury, scar formation, and others. This review summarizes the accomplishments of the field over the last years and discusses why Hsp are particularly suitable for CPP-mediated delivery.
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收藏
页码：167 / 174
页数：8
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